Mismatch repair deficiency, next-generation sequencing-based microsatellite instability, and tumor mutational burden as predictive biomarkers for immune checkpoint inhibitor effectiveness in frontline treatment of advanced stage endometrial cancer

OBJECTIVE: Molecular profiling is developing to inform treatment in endometrial cancer. Using real world evidence, we sought to evaluate frontline immune checkpoint inhibitor vs chemotherapy effectiveness in advanced endometrial cancer, stratified by Tumor Mutational Burden (TMB) ≥10 mut/MB and micr...

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Detalles Bibliográficos
Autores principales: Hill, Breana L, Graf, Ryon P, Shah, Kunal, Danziger, Natalie, Lin, Douglas I, Quintanilha, Julia, Li, Gerald, Haberberger, James, Ross, Jeffrey S, Santin, Alessandro D, Slomovitz, Brian, Elvin, Julia A, Eskander, Ramez N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086481/
https://www.ncbi.nlm.nih.gov/pubmed/36750267
http://dx.doi.org/10.1136/ijgc-2022-004026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086481/
https://www.ncbi.nlm.nih.gov/pubmed/36750267
http://dx.doi.org/10.1136/ijgc-2022-004026

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