Cargando…

Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism

BACKGROUND: Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade intestinal inflammation and, subsequently...

Descripción completa

Detalles Bibliográficos
Autores principales: Daniel, Noëmie, Gewirtz, Andrew T, Chassaing, Benoit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086484/
https://www.ncbi.nlm.nih.gov/pubmed/36646449
http://dx.doi.org/10.1136/gutjnl-2021-326835
_version_ 1785022163825197056
author Daniel, Noëmie
Gewirtz, Andrew T
Chassaing, Benoit
author_facet Daniel, Noëmie
Gewirtz, Andrew T
Chassaing, Benoit
author_sort Daniel, Noëmie
collection PubMed
description BACKGROUND: Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade intestinal inflammation and, subsequently, promotion of metabolic dysregulations. Detrimental impacts of emulsifier consumption on gut microbiota include depletion of the health-associated mucus-fortifying bacteria, Akkermansia muciniphila. OBJECTIVE: Investigate, in mice, the potential of administration of exogenous A. muciniphila as a means to protect against detrimental impacts of emulsifiers. RESULTS: Daily oral administration of A. muciniphila prevented phenotypic consequences of consumption of both CMC and P80, including hyperphagia, weight gain and dysglycaemia. A. muciniphila administration also counteracted the low-grade intestinal inflammation-induced CMC and P80. Furthermore, A. muciniphila supplementation prevented the proximal impacts of CMC and P80 on gut microbiota that are thought to drive low-grade chronic inflammation and metabolic dysregulations. Specifically, A. muciniphila prevented alterations in species composition and encroachment of gut microbiota that were otherwise induced by CMC and P80. Remarkably, we finally report that CMC and P80 altered the colonic transcriptome, while A. muciniphila largely protected against these alterations. CONCLUSION: Daily administration of A. muciniphila protects against the detrimental impact of emulsifiers on both the microbiota and host. These results support the notion that use of A. muciniphila as a probiotic can help maintain intestinal and metabolic health amidst the broad array of modern stresses that can promote chronic inflammatory diseases.
format Online
Article
Text
id pubmed-10086484
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher BMJ Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-100864842023-04-12 Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism Daniel, Noëmie Gewirtz, Andrew T Chassaing, Benoit Gut Gut Microbiota BACKGROUND: Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade intestinal inflammation and, subsequently, promotion of metabolic dysregulations. Detrimental impacts of emulsifier consumption on gut microbiota include depletion of the health-associated mucus-fortifying bacteria, Akkermansia muciniphila. OBJECTIVE: Investigate, in mice, the potential of administration of exogenous A. muciniphila as a means to protect against detrimental impacts of emulsifiers. RESULTS: Daily oral administration of A. muciniphila prevented phenotypic consequences of consumption of both CMC and P80, including hyperphagia, weight gain and dysglycaemia. A. muciniphila administration also counteracted the low-grade intestinal inflammation-induced CMC and P80. Furthermore, A. muciniphila supplementation prevented the proximal impacts of CMC and P80 on gut microbiota that are thought to drive low-grade chronic inflammation and metabolic dysregulations. Specifically, A. muciniphila prevented alterations in species composition and encroachment of gut microbiota that were otherwise induced by CMC and P80. Remarkably, we finally report that CMC and P80 altered the colonic transcriptome, while A. muciniphila largely protected against these alterations. CONCLUSION: Daily administration of A. muciniphila protects against the detrimental impact of emulsifiers on both the microbiota and host. These results support the notion that use of A. muciniphila as a probiotic can help maintain intestinal and metabolic health amidst the broad array of modern stresses that can promote chronic inflammatory diseases. BMJ Publishing Group 2023-05 2023-01-16 /pmc/articles/PMC10086484/ /pubmed/36646449 http://dx.doi.org/10.1136/gutjnl-2021-326835 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Gut Microbiota
Daniel, Noëmie
Gewirtz, Andrew T
Chassaing, Benoit
Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
title Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
title_full Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
title_fullStr Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
title_full_unstemmed Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
title_short Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
title_sort akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
topic Gut Microbiota
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086484/
https://www.ncbi.nlm.nih.gov/pubmed/36646449
http://dx.doi.org/10.1136/gutjnl-2021-326835
work_keys_str_mv AT danielnoemie akkermansiamuciniphilacounteractsthedeleteriouseffectsofdietaryemulsifiersonmicrobiotaandhostmetabolism
AT gewirtzandrewt akkermansiamuciniphilacounteractsthedeleteriouseffectsofdietaryemulsifiersonmicrobiotaandhostmetabolism
AT chassaingbenoit akkermansiamuciniphilacounteractsthedeleteriouseffectsofdietaryemulsifiersonmicrobiotaandhostmetabolism