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Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism
BACKGROUND: Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade intestinal inflammation and, subsequently...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086484/ https://www.ncbi.nlm.nih.gov/pubmed/36646449 http://dx.doi.org/10.1136/gutjnl-2021-326835 |
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author | Daniel, Noëmie Gewirtz, Andrew T Chassaing, Benoit |
author_facet | Daniel, Noëmie Gewirtz, Andrew T Chassaing, Benoit |
author_sort | Daniel, Noëmie |
collection | PubMed |
description | BACKGROUND: Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade intestinal inflammation and, subsequently, promotion of metabolic dysregulations. Detrimental impacts of emulsifier consumption on gut microbiota include depletion of the health-associated mucus-fortifying bacteria, Akkermansia muciniphila. OBJECTIVE: Investigate, in mice, the potential of administration of exogenous A. muciniphila as a means to protect against detrimental impacts of emulsifiers. RESULTS: Daily oral administration of A. muciniphila prevented phenotypic consequences of consumption of both CMC and P80, including hyperphagia, weight gain and dysglycaemia. A. muciniphila administration also counteracted the low-grade intestinal inflammation-induced CMC and P80. Furthermore, A. muciniphila supplementation prevented the proximal impacts of CMC and P80 on gut microbiota that are thought to drive low-grade chronic inflammation and metabolic dysregulations. Specifically, A. muciniphila prevented alterations in species composition and encroachment of gut microbiota that were otherwise induced by CMC and P80. Remarkably, we finally report that CMC and P80 altered the colonic transcriptome, while A. muciniphila largely protected against these alterations. CONCLUSION: Daily administration of A. muciniphila protects against the detrimental impact of emulsifiers on both the microbiota and host. These results support the notion that use of A. muciniphila as a probiotic can help maintain intestinal and metabolic health amidst the broad array of modern stresses that can promote chronic inflammatory diseases. |
format | Online Article Text |
id | pubmed-10086484 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-100864842023-04-12 Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism Daniel, Noëmie Gewirtz, Andrew T Chassaing, Benoit Gut Gut Microbiota BACKGROUND: Accumulating evidence indicates that some non-absorbed food additives, including emulsifiers carboxymethylcellulose (CMC) and polysorbate 80 (P80), can negatively impact intestinal microbiota, leading to microbiota encroachment, chronic low-grade intestinal inflammation and, subsequently, promotion of metabolic dysregulations. Detrimental impacts of emulsifier consumption on gut microbiota include depletion of the health-associated mucus-fortifying bacteria, Akkermansia muciniphila. OBJECTIVE: Investigate, in mice, the potential of administration of exogenous A. muciniphila as a means to protect against detrimental impacts of emulsifiers. RESULTS: Daily oral administration of A. muciniphila prevented phenotypic consequences of consumption of both CMC and P80, including hyperphagia, weight gain and dysglycaemia. A. muciniphila administration also counteracted the low-grade intestinal inflammation-induced CMC and P80. Furthermore, A. muciniphila supplementation prevented the proximal impacts of CMC and P80 on gut microbiota that are thought to drive low-grade chronic inflammation and metabolic dysregulations. Specifically, A. muciniphila prevented alterations in species composition and encroachment of gut microbiota that were otherwise induced by CMC and P80. Remarkably, we finally report that CMC and P80 altered the colonic transcriptome, while A. muciniphila largely protected against these alterations. CONCLUSION: Daily administration of A. muciniphila protects against the detrimental impact of emulsifiers on both the microbiota and host. These results support the notion that use of A. muciniphila as a probiotic can help maintain intestinal and metabolic health amidst the broad array of modern stresses that can promote chronic inflammatory diseases. BMJ Publishing Group 2023-05 2023-01-16 /pmc/articles/PMC10086484/ /pubmed/36646449 http://dx.doi.org/10.1136/gutjnl-2021-326835 Text en © Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Gut Microbiota Daniel, Noëmie Gewirtz, Andrew T Chassaing, Benoit Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism |
title |
Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism |
title_full |
Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism |
title_fullStr |
Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism |
title_full_unstemmed |
Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism |
title_short |
Akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism |
title_sort | akkermansia muciniphila counteracts the deleterious effects of dietary emulsifiers on microbiota and host metabolism |
topic | Gut Microbiota |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086484/ https://www.ncbi.nlm.nih.gov/pubmed/36646449 http://dx.doi.org/10.1136/gutjnl-2021-326835 |
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