Single-cell RNA-seq analysis reveals BHLHE40-driven pro-tumour neutrophils with hyperactivated glycolysis in pancreatic tumour microenvironment

OBJECTIVE: Innate immunity plays important roles in pancreatic ductal adenocarcinoma (PDAC), as non-T-cell-enriched tumour. Neutrophils are major players in innate immune system. Here, we aimed to explore the heterogeneity and pro-tumour mechanisms of neutrophils in PDAC. DESIGN: We analysed single-...

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Detalles Bibliográficos
Autores principales: Wang, Liwen, Liu, Yihao, Dai, Yuting, Tang, Xiaomei, Yin, Tong, Wang, Chaofu, Wang, Ting, Dong, Lei, Shi, Minmin, Qin, Jiejie, Xue, Meilin, Cao, Yizhi, Liu, Jia, Liu, Pengyi, Huang, Jinyan, Wen, Chenlei, Zhang, Jun, Xu, Zhiwei, Bai, Fan, Deng, Xiaxing, Peng, Chenghong, Chen, Hao, Jiang, Lingxi, Chen, Saijuan, Shen, Baiyong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2023
Materias:
Pancreas
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086491/
https://www.ncbi.nlm.nih.gov/pubmed/35688610
http://dx.doi.org/10.1136/gutjnl-2021-326070

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