RUNX1 Upregulation Causes Mitochondrial Dysfunction via Regulating the PI3K-Akt Pathway in iPSC from Patients with Down Syndrome

Down syndrome (DS) is the most common autosomal aneuploidy caused by trisomy of chromosome 21. Previous studies demonstrated that DS affected mitochondrial functions, which may be associated with the abnormal development of the nervous system in patients with DS. Runt-related transcription factor 1...

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Detalles Bibliográficos
Autores principales: Liu, Yanna, Zhang, Yuehua, Ren, Zhaorui, Zeng, Fanyi, Yan, Jingbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086551/
https://www.ncbi.nlm.nih.gov/pubmed/36625318
http://dx.doi.org/10.14348/molcells.2023.2095

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