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7α,25-Dihydroxycholesterol-Induced Oxiapoptophagic Chondrocyte Death via the Modulation of p53-Akt-mTOR Axis in Osteoarthritis Pathogenesis

This study aimed to exploring the pathophysiological mechanism of 7α,25-dihydroxycholesterol (7α,25-DHC) in osteoarthritis (OA) pathogenesis. 7α,25-DHC accelerated the proteoglycan loss in ex vivo organ-cultured articular cartilage explant. It was mediated by the decreasing extracellular matrix majo...

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Detalles Bibliográficos
Autores principales:	Seo, Jeong-Yeon, Kim, Tae-Hyeon, Kang, Kyeong-Rok, Lim, HyangI, Choi, Moon-Chang, Kim, Do Kyung, Chun, Hong Sung, Kim, Heung-Joong, Yu, Sun-Kyoung, Kim, Jae-Sung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086556/ https://www.ncbi.nlm.nih.gov/pubmed/36896597 http://dx.doi.org/10.14348/molcells.2023.2149

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