Unravelling homologous recombination repair deficiency and therapeutic opportunities in soft tissue and bone sarcoma

Defects in homologous recombination repair (HRR) in tumors correlate with poor prognosis and metastases development. Determining HRR deficiency (HRD) is of major clinical relevance as it is associated with therapeutic vulnerabilities and remains poorly investigated in sarcoma. Here, we show that spe...

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Detalles Bibliográficos
Autores principales: Planas‐Paz, Lara, Pliego‐Mendieta, Alicia, Hagedorn, Catherine, Aguilera‐Garcia, Domingo, Haberecker, Martina, Arnold, Fabian, Herzog, Marius, Bankel, Lorenz, Guggenberger, Roman, Steiner, Sabrina, Chen, Yanjiang, Kahraman, Abdullah, Zoche, Martin, Rubin, Mark A, Moch, Holger, Britschgi, Christian, Pauli, Chantal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086583/
https://www.ncbi.nlm.nih.gov/pubmed/36779660
http://dx.doi.org/10.15252/emmm.202216863

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086583/
https://www.ncbi.nlm.nih.gov/pubmed/36779660
http://dx.doi.org/10.15252/emmm.202216863

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