Cargando…

Nanobody‐mediated complement activation to kill HIV‐infected cells

The complement system which is part of the innate immune response against invading pathogens represents a powerful mechanism for killing of infected cells. Utilizing direct complement recruitment for complement‐mediated elimination of HIV‐1‐infected cells is underexplored. We developed a novel thera...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pedersen, Maria Lange, Pedersen, Dennis Vestergaard, Winkler, Mikael Becher Lykkegaard, Olesen, Heidi Gytz, Søgaard, Ole Schmeltz, Østergaard, Lars, Laursen, Nick Stub, Rahimic, Anna Halling Folkmar, Tolstrup, Martin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086584/ https://www.ncbi.nlm.nih.gov/pubmed/36799046 http://dx.doi.org/10.15252/emmm.202216422

Ejemplares similares

Comparable human reconstitution following Cesium-137 versus X-ray irradiation preconditioning in immunodeficient NOG mice
por: Andersen, Anna Halling Folkmar, et al.
Publicado: (2020)

CD169 (Siglec-1) as a Robust Human Cell Biomarker of Toll-Like Receptor 9 Agonist Immunotherapy
por: Lende, Stine Sofie Frank, et al.
Publicado: (2022)

Structure-Guided Engineering of a Complement Component C3-Binding Nanobody Improves Specificity and Adds Cofactor Activity
por: Pedersen, Henrik, et al.
Publicado: (2022)

Nanobodies Provide Insight into the Molecular Mechanisms of the Complement Cascade and Offer New Therapeutic Strategies
por: Zarantonello, Alessandra, et al.
Publicado: (2021)

The Potential of Long-Acting, Tissue-Targeted Synthetic Nanotherapy for Delivery of Antiviral Therapy Against HIV Infection
por: Halling Folkmar Andersen, Anna, et al.
Publicado: (2020)

Discovery of neutralizing SARS-CoV-2 antibodies enriched in a unique antigen specific B cell cluster
por: Lende, Stine Sofie Frank, et al.
Publicado: (2023)

Structural insights into the function-modulating effects of nanobody binding to the integrin receptor α(M)β(2)
por: Jensen, Rasmus K., et al.
Publicado: (2022)

Functional and Structural Characterization of a Potent C1q Inhibitor Targeting the Classical Pathway of the Complement System
por: Laursen, Nick S., et al.
Publicado: (2020)

Strategies for enhancing CAR T cell expansion and persistence in HIV infection
por: Rothemejer, Frederik Holm, et al.
Publicado: (2023)

Activation of Latent Human Immunodeficiency Virus by the Histone Deacetylase Inhibitor Panobinostat: A Pilot Study to Assess Effects on the Central Nervous System
por: Rasmussen, Thomas A., et al.
Publicado: (2015)

Introducing site-specific cysteines into nanobodies for mercury labelling allows de novo phasing of their crystal structures
por: Hansen, Simon Boje, et al.
Publicado: (2017)

Comparison of HDAC inhibitors in clinical development: Effect on HIV production in latently infected cells and T-cell activation
por: Rasmussen, Thomas Aagaard, et al.
Publicado: (2013)

Immune checkpoints and the HIV-1 reservoir: proceed with caution
por: Olesen, Rikke, et al.
Publicado: (2016)

Structure determination of an unstable macromolecular complex enabled by nanobody‐peptide bridging
por: Lorentzen, Josefine, et al.
Publicado: (2022)

Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase
por: Longhin, Elena, et al.
Publicado: (2018)

Endotoxemia Is Associated with Altered Innate and Adaptive Immune Responses in Untreated HIV-1 Infected Individuals
por: Bukh, Anne Roslev, et al.
Publicado: (2011)

Redirector of Vaccine-induced Effector Responses (RoVER) for specific killing of cellular targets
por: Konrad, Christina V., et al.
Publicado: (2023)

The Use of Toll-Like Receptor Agonists in HIV-1 Cure Strategies
por: Martinsen, Janne Tegder, et al.
Publicado: (2020)

Characteristics associated with serological COVID-19 vaccine response and durability in an older population with significant comorbidity: author's response
por: Søgaard, Ole Schmeltz
Publicado: (2022)

Treatment of HIV-Infected Individuals with the Histone Deacetylase Inhibitor Panobinostat Results in Increased Numbers of Regulatory T Cells and Limits Ex Vivo Lipopolysaccharide-Induced Inflammatory Responses
por: Brinkmann, Christel Rothe, et al.
Publicado: (2018)

Fimepinostat, a novel dual inhibitor of HDAC and PI3K, effectively reverses HIV-1 latency ex vivo without T cell activation
por: Gunst, Jesper D, et al.
Publicado: (2019)

Eliminating the latent HIV reservoir by reactivation strategies: Advancing to clinical trials
por: Rasmussen, Thomas A., et al.
Publicado: (2013)

TLR-Agonist Mediated Enhancement of Antibody-Dependent Effector Functions as Strategy For an HIV-1 Cure
por: Hvilsom, Caroline Thue, et al.
Publicado: (2021)

Schizophrenia: Complement Cleaning or Killing
por: Hogenaar, Jirrine T.T., et al.
Publicado: (2021)

Risk of human papillomavirus-related cancers among kidney transplant recipients and patients receiving chronic dialysis - an observational cohort study
por: Skov Dalgaard, Lars, et al.
Publicado: (2013)

Risk and outcome of pyelonephritis among renal transplant recipients
por: Graversen, Mette Elneff, et al.
Publicado: (2016)

Polysaccharide Responsiveness Is Not Biased by Prior Pneumococcal-Conjugate Vaccination
por: Bernth-Jensen, Jens Magnus, et al.
Publicado: (2013)

TLR9-adjuvanted pneumococcal conjugate vaccine induces antibody-independent memory responses in HIV-infected adults
por: Offersen, Rasmus, et al.
Publicado: (2012)

Multifaceted Activities of Seven Nanobodies against Complement C4b
por: De la O Becerra, Karla I., et al.
Publicado: (2022)

Heterologous COVID-19 vaccination as a strategy to accelerate mass immunization
por: Klastrup, Vibeke, et al.
Publicado: (2022)

Broad activation of latent HIV-1 in vivo
por: Barton, Kirston, et al.
Publicado: (2016)

Development of HIV-Resistant CAR T Cells by CRISPR/Cas-Mediated CAR Integration into the CCR5 Locus
por: Rothemejer, Frederik Holm, et al.
Publicado: (2023)

Long-term humoral and cellular immunity after primary SARS-CoV-2 infection: a 20-month longitudinal study
por: Hvidt, Astrid Korning, et al.
Publicado: (2023)

Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells
por: De Groof, Timo W. M., et al.
Publicado: (2019)

Targeting the latent human cytomegalovirus reservoir for T-cell-mediated killing with virus-specific nanobodies
por: De Groof, Timo W. M., et al.
Publicado: (2021)

Risk and Prognosis of Bloodstream Infections among Patients on Chronic Hemodialysis: A Population-Based Cohort Study
por: Skov Dalgaard, Lars, et al.
Publicado: (2015)

Mortality after Hospitalization for Pneumonia among Individuals with HIV, 1995–2008: A Danish Cohort Study
por: Søgaard, Ole S., et al.
Publicado: (2009)

The Impact of B-Cell Perturbations on Pneumococcal Conjugate Vaccine Response in HIV-Infected Adults
por: Johannesson, Thomas G., et al.
Publicado: (2012)

Inflammation and Platelet Activation After COVID-19 Vaccines - Possible Mechanisms Behind Vaccine-Induced Immune Thrombocytopenia and Thrombosis
por: Ostrowski, Sisse R., et al.
Publicado: (2021)

Generation of a CD70-Specific Fusion Nanobody with IgG Recruiting Capacity for Tumor Killing
por: Liu, Chang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_1edjdf0j73bmflbqdcqu4brq1n