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Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations

PURPOSE: Liver biopsy is still the standard method for the diagnosis of ductal plate malformations (DPM). However, it is an invasive tool. Magnetic resonance imaging (MRI) has shown its accuracy in the diagnosis of this pathology. Herein, a study was conducted to elucidate the role of diffusion MRI...

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Autores principales: Elhawary, Mohammed, Elmansy, Mostafa, Ali, Khadiga, Abdallah, Ebtesam, Razek, Ahmed, Barakat, Tarik, Sarhan, Amr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Termedia Publishing House 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086607/
https://www.ncbi.nlm.nih.gov/pubmed/37057198
http://dx.doi.org/10.5114/pjr.2023.125865
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author Elhawary, Mohammed
Elmansy, Mostafa
Ali, Khadiga
Abdallah, Ebtesam
Razek, Ahmed
Barakat, Tarik
Sarhan, Amr
author_facet Elhawary, Mohammed
Elmansy, Mostafa
Ali, Khadiga
Abdallah, Ebtesam
Razek, Ahmed
Barakat, Tarik
Sarhan, Amr
author_sort Elhawary, Mohammed
collection PubMed
description PURPOSE: Liver biopsy is still the standard method for the diagnosis of ductal plate malformations (DPM). However, it is an invasive tool. Magnetic resonance imaging (MRI) has shown its accuracy in the diagnosis of this pathology. Herein, a study was conducted to elucidate the role of diffusion MRI parameters in predicting the degree of hepatic fibrosis. MATERIAL AND METHODS: This prospective study included 29 patients with DPM and 20 healthy controls. Both groups underwent diffusion tensor magnetic resonance imaging (DT-MRI), and its parameters were compared between patients and controls, and then they were correlated with the degree of liver fibrosis in the patient group. RESULTS: All patients with DPM, whatever its type, expressed a significantly lower hepatic apparent diffusion coefficient (ADC) compared to controls. However, fractional anisotropy (FA) showed no significant difference between them. The ADC value of 1.65 × 10(-3) mm(2)/s had sensitivity and specificity of 82.1% and 90%, respectively, in differentiating DPM patients from healthy controls. It was evident that patients with higher fibrosis grades had significantly lower hepatic ADC, indicating a negative correlation between ADC and the grade of hepatic fibrosis; rs = –0.901, p < 0.001. CONCLUSIONS: DT-MRI showed good efficacy in the diagnosis of congenital DPM. Moreover, ADC could be applied to monitor the degree of liver fibrosis rather than the invasive liver biopsy. No significant correlation was noted between the FA and the grades of liver fibrosis.
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spelling pubmed-100866072023-04-12 Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations Elhawary, Mohammed Elmansy, Mostafa Ali, Khadiga Abdallah, Ebtesam Razek, Ahmed Barakat, Tarik Sarhan, Amr Pol J Radiol Original Paper PURPOSE: Liver biopsy is still the standard method for the diagnosis of ductal plate malformations (DPM). However, it is an invasive tool. Magnetic resonance imaging (MRI) has shown its accuracy in the diagnosis of this pathology. Herein, a study was conducted to elucidate the role of diffusion MRI parameters in predicting the degree of hepatic fibrosis. MATERIAL AND METHODS: This prospective study included 29 patients with DPM and 20 healthy controls. Both groups underwent diffusion tensor magnetic resonance imaging (DT-MRI), and its parameters were compared between patients and controls, and then they were correlated with the degree of liver fibrosis in the patient group. RESULTS: All patients with DPM, whatever its type, expressed a significantly lower hepatic apparent diffusion coefficient (ADC) compared to controls. However, fractional anisotropy (FA) showed no significant difference between them. The ADC value of 1.65 × 10(-3) mm(2)/s had sensitivity and specificity of 82.1% and 90%, respectively, in differentiating DPM patients from healthy controls. It was evident that patients with higher fibrosis grades had significantly lower hepatic ADC, indicating a negative correlation between ADC and the grade of hepatic fibrosis; rs = –0.901, p < 0.001. CONCLUSIONS: DT-MRI showed good efficacy in the diagnosis of congenital DPM. Moreover, ADC could be applied to monitor the degree of liver fibrosis rather than the invasive liver biopsy. No significant correlation was noted between the FA and the grades of liver fibrosis. Termedia Publishing House 2023-03-08 /pmc/articles/PMC10086607/ /pubmed/37057198 http://dx.doi.org/10.5114/pjr.2023.125865 Text en © Pol J Radiol 2023 https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0). License (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle Original Paper
Elhawary, Mohammed
Elmansy, Mostafa
Ali, Khadiga
Abdallah, Ebtesam
Razek, Ahmed
Barakat, Tarik
Sarhan, Amr
Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations
title Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations
title_full Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations
title_fullStr Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations
title_full_unstemmed Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations
title_short Diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations
title_sort diffusion tensor magnetic resonance imaging in the grading of liver fibrosis associated with congenital ductal plate malformations
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086607/
https://www.ncbi.nlm.nih.gov/pubmed/37057198
http://dx.doi.org/10.5114/pjr.2023.125865
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