Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions

A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)–based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody...

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Detalles Bibliográficos
Autores principales: Lam, W K Jacky, King, Ann D, Miller, Jacob A, Liu, Zhiwei, Yu, Kelly J, Chua, Melvin L K, Ma, Brigette B Y, Chen, Ming Yuan, Pinsky, Benjamin A, Lou, Pei-Jen, Woo, John K S, Hsu, Wan-Lun, Simon, Julia, Doolan, Denise L, Waterboer, Tim, Hui, Edwin P, Li, Hui, Tsang, Raymond K, Wong, Kenneth C W, Goh, Julian P, Vlantis, Alexander C, Ai, Qi Yong, Wong, Lun M, Abdullah, Victor, Lin, Jin Ching, Chen, Chien-Jen, Pfeiffer, Ruth M, Le, Quynh-Thu, Lee, Anne W M, Ji, Mingfang, Cao, Sumei, Ma, Jun, Chan, Anthony T C, Chan, K C Allen, Hildesheim, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086631/
https://www.ncbi.nlm.nih.gov/pubmed/36723440
http://dx.doi.org/10.1093/jnci/djad012
Descripción
Sumario:A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)–based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.

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