Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions

A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)–based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody...

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Autores principales: Lam, W K Jacky, King, Ann D, Miller, Jacob A, Liu, Zhiwei, Yu, Kelly J, Chua, Melvin L K, Ma, Brigette B Y, Chen, Ming Yuan, Pinsky, Benjamin A, Lou, Pei-Jen, Woo, John K S, Hsu, Wan-Lun, Simon, Julia, Doolan, Denise L, Waterboer, Tim, Hui, Edwin P, Li, Hui, Tsang, Raymond K, Wong, Kenneth C W, Goh, Julian P, Vlantis, Alexander C, Ai, Qi Yong, Wong, Lun M, Abdullah, Victor, Lin, Jin Ching, Chen, Chien-Jen, Pfeiffer, Ruth M, Le, Quynh-Thu, Lee, Anne W M, Ji, Mingfang, Cao, Sumei, Ma, Jun, Chan, Anthony T C, Chan, K C Allen, Hildesheim, Allan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086631/
https://www.ncbi.nlm.nih.gov/pubmed/36723440
http://dx.doi.org/10.1093/jnci/djad012
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author Lam, W K Jacky
King, Ann D
Miller, Jacob A
Liu, Zhiwei
Yu, Kelly J
Chua, Melvin L K
Ma, Brigette B Y
Chen, Ming Yuan
Pinsky, Benjamin A
Lou, Pei-Jen
Woo, John K S
Hsu, Wan-Lun
Simon, Julia
Doolan, Denise L
Waterboer, Tim
Hui, Edwin P
Li, Hui
Tsang, Raymond K
Wong, Kenneth C W
Goh, Julian P
Vlantis, Alexander C
Ai, Qi Yong
Wong, Lun M
Abdullah, Victor
Lin, Jin Ching
Chen, Chien-Jen
Pfeiffer, Ruth M
Le, Quynh-Thu
Lee, Anne W M
Ji, Mingfang
Cao, Sumei
Ma, Jun
Chan, Anthony T C
Chan, K C Allen
Hildesheim, Allan
author_facet Lam, W K Jacky
King, Ann D
Miller, Jacob A
Liu, Zhiwei
Yu, Kelly J
Chua, Melvin L K
Ma, Brigette B Y
Chen, Ming Yuan
Pinsky, Benjamin A
Lou, Pei-Jen
Woo, John K S
Hsu, Wan-Lun
Simon, Julia
Doolan, Denise L
Waterboer, Tim
Hui, Edwin P
Li, Hui
Tsang, Raymond K
Wong, Kenneth C W
Goh, Julian P
Vlantis, Alexander C
Ai, Qi Yong
Wong, Lun M
Abdullah, Victor
Lin, Jin Ching
Chen, Chien-Jen
Pfeiffer, Ruth M
Le, Quynh-Thu
Lee, Anne W M
Ji, Mingfang
Cao, Sumei
Ma, Jun
Chan, Anthony T C
Chan, K C Allen
Hildesheim, Allan
author_sort Lam, W K Jacky
collection PubMed
description A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)–based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program.
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spelling pubmed-100866312023-04-12 Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions Lam, W K Jacky King, Ann D Miller, Jacob A Liu, Zhiwei Yu, Kelly J Chua, Melvin L K Ma, Brigette B Y Chen, Ming Yuan Pinsky, Benjamin A Lou, Pei-Jen Woo, John K S Hsu, Wan-Lun Simon, Julia Doolan, Denise L Waterboer, Tim Hui, Edwin P Li, Hui Tsang, Raymond K Wong, Kenneth C W Goh, Julian P Vlantis, Alexander C Ai, Qi Yong Wong, Lun M Abdullah, Victor Lin, Jin Ching Chen, Chien-Jen Pfeiffer, Ruth M Le, Quynh-Thu Lee, Anne W M Ji, Mingfang Cao, Sumei Ma, Jun Chan, Anthony T C Chan, K C Allen Hildesheim, Allan J Natl Cancer Inst Commentary A meeting of experts was held in November 2021 to review and discuss available data on performance of Epstein-Barr virus (EBV)–based approaches to screen for early stage nasopharyngeal carcinoma (NPC) and methods for the investigation and management of screen-positive individuals. Serum EBV antibody and plasma EBV DNA testing methods were considered. Both approaches were found to have favorable performance characteristics and to be cost-effective in high-risk populations. In addition to endoscopy, use of magnetic resonance imaging (MRI) to investigate screen-positive individuals was found to increase the sensitivity of NPC detection with minimal impact on cost-effectiveness of the screening program. Oxford University Press 2023-02-01 /pmc/articles/PMC10086631/ /pubmed/36723440 http://dx.doi.org/10.1093/jnci/djad012 Text en © The Author(s) 2023. Published by Oxford University Press. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Commentary
Lam, W K Jacky
King, Ann D
Miller, Jacob A
Liu, Zhiwei
Yu, Kelly J
Chua, Melvin L K
Ma, Brigette B Y
Chen, Ming Yuan
Pinsky, Benjamin A
Lou, Pei-Jen
Woo, John K S
Hsu, Wan-Lun
Simon, Julia
Doolan, Denise L
Waterboer, Tim
Hui, Edwin P
Li, Hui
Tsang, Raymond K
Wong, Kenneth C W
Goh, Julian P
Vlantis, Alexander C
Ai, Qi Yong
Wong, Lun M
Abdullah, Victor
Lin, Jin Ching
Chen, Chien-Jen
Pfeiffer, Ruth M
Le, Quynh-Thu
Lee, Anne W M
Ji, Mingfang
Cao, Sumei
Ma, Jun
Chan, Anthony T C
Chan, K C Allen
Hildesheim, Allan
Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions
title Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions
title_full Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions
title_fullStr Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions
title_full_unstemmed Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions
title_short Recommendations for Epstein-Barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions
title_sort recommendations for epstein-barr virus–based screening for nasopharyngeal cancer in high- and intermediate-risk regions
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086631/
https://www.ncbi.nlm.nih.gov/pubmed/36723440
http://dx.doi.org/10.1093/jnci/djad012
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