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Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters

INTRODUCTION: Firefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early d...

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Autores principales: Kisiel, Marta A., Cai, Gui-Hong, Petersson Sjögren, Madeleine, Löndahl, Jakob, Jakobsson, Jonas, Wollmer, Per, Malinovschi, Andrei, Svartengren, Magnus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Respiratory Society 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086739/
https://www.ncbi.nlm.nih.gov/pubmed/37057087
http://dx.doi.org/10.1183/23120541.00504-2022
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author Kisiel, Marta A.
Cai, Gui-Hong
Petersson Sjögren, Madeleine
Löndahl, Jakob
Jakobsson, Jonas
Wollmer, Per
Malinovschi, Andrei
Svartengren, Magnus
author_facet Kisiel, Marta A.
Cai, Gui-Hong
Petersson Sjögren, Madeleine
Löndahl, Jakob
Jakobsson, Jonas
Wollmer, Per
Malinovschi, Andrei
Svartengren, Magnus
author_sort Kisiel, Marta A.
collection PubMed
description INTRODUCTION: Firefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early detection of emphysema in COPD. This method may be useful in the occupational setting to detect early pulmonary changes and enable prevention. The aim of the present study was to evaluate whether AiDA detects changes in the most peripheral airways of firefighters. METHODS: AiDA, measuring the effective airspace radius (r(AiDA)) and zero-second recovery (R(0)), was used as a complement to other standardised lung function measures in 21 male firefighters and 16 age-matched male controls. RESULTS: There were significant differences in r(AiDA) and R(0) between firefighters (mean±sd r(AiDA) 0.301±0.024 mm; mean±sd R(0) 0.336±0.116 arbitrary units) and controls (mean±sd r(AiDA) 0.276±0.044 mm; mean±sd R(0) 0.5760.168 arbitrary units), p=0.03 and p<0.001, respectively. Higher forced vital capacity was found in firefighters (mean 101% of predicted) than in controls (mean 93% of predicted; p=0.03). No significant differences were found with regard to either the ratio between forced expiratory volume in 1 s and forced vital capacity or forced expiratory volume in 1 s. The majority of firefighters had diffusing capacity of the lung for carbon monoxide, oscillometry and single-breath nitrogen washout values within the normal ranges. CONCLUSION: AiDA parameters can provide information on early pulmonary peripheral changes that may not be seen with standard techniques used in screening of pulmonary function.
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spelling pubmed-100867392023-04-12 Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters Kisiel, Marta A. Cai, Gui-Hong Petersson Sjögren, Madeleine Löndahl, Jakob Jakobsson, Jonas Wollmer, Per Malinovschi, Andrei Svartengren, Magnus ERJ Open Res Original Research Articles INTRODUCTION: Firefighters have increased risk of chronic respiratory disease. Standard clinical techniques used in medical checkups may not detect the earliest microstructural changes in peripheral airways. A new technique called Airspace Dimension Assessment (AiDA) has been shown to enable early detection of emphysema in COPD. This method may be useful in the occupational setting to detect early pulmonary changes and enable prevention. The aim of the present study was to evaluate whether AiDA detects changes in the most peripheral airways of firefighters. METHODS: AiDA, measuring the effective airspace radius (r(AiDA)) and zero-second recovery (R(0)), was used as a complement to other standardised lung function measures in 21 male firefighters and 16 age-matched male controls. RESULTS: There were significant differences in r(AiDA) and R(0) between firefighters (mean±sd r(AiDA) 0.301±0.024 mm; mean±sd R(0) 0.336±0.116 arbitrary units) and controls (mean±sd r(AiDA) 0.276±0.044 mm; mean±sd R(0) 0.5760.168 arbitrary units), p=0.03 and p<0.001, respectively. Higher forced vital capacity was found in firefighters (mean 101% of predicted) than in controls (mean 93% of predicted; p=0.03). No significant differences were found with regard to either the ratio between forced expiratory volume in 1 s and forced vital capacity or forced expiratory volume in 1 s. The majority of firefighters had diffusing capacity of the lung for carbon monoxide, oscillometry and single-breath nitrogen washout values within the normal ranges. CONCLUSION: AiDA parameters can provide information on early pulmonary peripheral changes that may not be seen with standard techniques used in screening of pulmonary function. European Respiratory Society 2023-04-11 /pmc/articles/PMC10086739/ /pubmed/37057087 http://dx.doi.org/10.1183/23120541.00504-2022 Text en Copyright ©The authors 2023 https://creativecommons.org/licenses/by-nc/4.0/This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0. For commercial reproduction rights and permissions contact permissions@ersnet.org (mailto:permissions@ersnet.org)
spellingShingle Original Research Articles
Kisiel, Marta A.
Cai, Gui-Hong
Petersson Sjögren, Madeleine
Löndahl, Jakob
Jakobsson, Jonas
Wollmer, Per
Malinovschi, Andrei
Svartengren, Magnus
Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters
title Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters
title_full Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters
title_fullStr Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters
title_full_unstemmed Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters
title_short Airspace Dimension Assessment for early detection of lung function impairment in the peripheral airways of firefighters
title_sort airspace dimension assessment for early detection of lung function impairment in the peripheral airways of firefighters
topic Original Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086739/
https://www.ncbi.nlm.nih.gov/pubmed/37057087
http://dx.doi.org/10.1183/23120541.00504-2022
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