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Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions
Polylactic acid (PLA) has been extensively used for the manufacturing of scaffolds in bone tissue engineering applications. Due to the low hydrophilicity and the acidic degradation process of this biomaterial, different strategies have been proposed to increase the biofunctionality of the support st...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086817/ https://www.ncbi.nlm.nih.gov/pubmed/36069281 http://dx.doi.org/10.1002/jbm.b.35162 |
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author | Donate, Ricardo Monzón, Mario Alemán‐Domínguez, María Elena Rodríguez‐Esparragón, Francisco |
author_facet | Donate, Ricardo Monzón, Mario Alemán‐Domínguez, María Elena Rodríguez‐Esparragón, Francisco |
author_sort | Donate, Ricardo |
collection | PubMed |
description | Polylactic acid (PLA) has been extensively used for the manufacturing of scaffolds in bone tissue engineering applications. Due to the low hydrophilicity and the acidic degradation process of this biomaterial, different strategies have been proposed to increase the biofunctionality of the support structure. The use of ceramic particles is a generally preferred option to increase the osteoconductivity of the base material, while acting as buffers to maintain the pH level of the surroundings tissues. Surface modification is another approach to overcome the limitations of PLA for tissue engineering applications. In this work, the degradation profile of 3D‐printed PLA scaffolds containing beta‐tricalcium phosphate (β‐TCP) and calcium carbonate (CaCO(3)) particles has been studied under hydrolytic conditions. Composite samples treated with plasma and coated with Aloe vera extracts were also studied to evaluate the effect of this surface modification method. The characterization of the 3D structures included its morphological, calorimetric and mechanical evaluation. According to the results obtained, the proposed composite scaffolds allowed an adequate maintenance of the pH level of the surrounding medium, with no effects observed on the morphology and mechanical properties of these structures. Hence, these samples showed potential to be further investigated as candidates for bone tissue regeneration. |
format | Online Article Text |
id | pubmed-10086817 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley & Sons, Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100868172023-04-12 Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions Donate, Ricardo Monzón, Mario Alemán‐Domínguez, María Elena Rodríguez‐Esparragón, Francisco J Biomed Mater Res B Appl Biomater Research Articles Polylactic acid (PLA) has been extensively used for the manufacturing of scaffolds in bone tissue engineering applications. Due to the low hydrophilicity and the acidic degradation process of this biomaterial, different strategies have been proposed to increase the biofunctionality of the support structure. The use of ceramic particles is a generally preferred option to increase the osteoconductivity of the base material, while acting as buffers to maintain the pH level of the surroundings tissues. Surface modification is another approach to overcome the limitations of PLA for tissue engineering applications. In this work, the degradation profile of 3D‐printed PLA scaffolds containing beta‐tricalcium phosphate (β‐TCP) and calcium carbonate (CaCO(3)) particles has been studied under hydrolytic conditions. Composite samples treated with plasma and coated with Aloe vera extracts were also studied to evaluate the effect of this surface modification method. The characterization of the 3D structures included its morphological, calorimetric and mechanical evaluation. According to the results obtained, the proposed composite scaffolds allowed an adequate maintenance of the pH level of the surrounding medium, with no effects observed on the morphology and mechanical properties of these structures. Hence, these samples showed potential to be further investigated as candidates for bone tissue regeneration. John Wiley & Sons, Inc. 2022-09-07 2023-02 /pmc/articles/PMC10086817/ /pubmed/36069281 http://dx.doi.org/10.1002/jbm.b.35162 Text en © 2022 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Research Articles Donate, Ricardo Monzón, Mario Alemán‐Domínguez, María Elena Rodríguez‐Esparragón, Francisco Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions |
title | Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions |
title_full | Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions |
title_fullStr | Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions |
title_full_unstemmed | Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions |
title_short | Effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions |
title_sort | effects of ceramic additives and bioactive coatings on the degradation of polylactic acid‐based bone scaffolds under hydrolytic conditions |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10086817/ https://www.ncbi.nlm.nih.gov/pubmed/36069281 http://dx.doi.org/10.1002/jbm.b.35162 |
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