DKK1 drives immune suppressive phenotypes in intrahepatic cholangiocarcinoma and can be targeted with anti‐DKK1 therapeutic DKN‐01

BACKGROUND AND AIMS: Dickkopf‐1 (DKK1) is associated with poor prognosis in intrahepatic cholangiocarcinoma (iCCA), but the mechanisms behind this are unclear. Here, we show that DKK1 plays an immune regulatory role in vivo and inhibition reduces tumour growth. METHODS: Various in vivo GEMM mouse mo...

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Detalles Bibliográficos
Autores principales: Jarman, Edward J., Horcas‐Lopez, Marta, Waddell, Scott H., MacMaster, Stephanie, Gournopanos, Konstantinos, Soong, Daniel Y. H., Musialik, Kamila I., Tsokkou, Panagiota, Ng, Minn‐E, Cambridge, William A., Wilson, David H., Kagey, Michael H., Newman, Walter, Pollard, Jeffrey W., Boulter, Luke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Liver Cancer
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087034/
https://www.ncbi.nlm.nih.gov/pubmed/35924447
http://dx.doi.org/10.1111/liv.15383

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