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Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort

OBJECTIVE: As first‐degree relatives (FDRs) of HLA–B27–positive patients with axial spondyloarthritis (SpA) have an increased risk of developing axial SpA, the objectives were 1) to evaluate the presence of highly specific imaging features as well as clinical signs of SpA at baseline and after 1 yea...

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Autores principales: de Jong, Henriëtte M. Y., de Winter, Janneke J. H., van der Horst‐Bruinsma, Irene E., van Schaardenburg, Dirk‐Jan, van Gaalen, Floris A., van Tubergen, Astrid M., Weel, Angelique E. A. M., Landewé, Robert B. M., Baeten, Dominique L. P., van de Sande, Marleen G. H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087210/
https://www.ncbi.nlm.nih.gov/pubmed/34219406
http://dx.doi.org/10.1002/acr.24743
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author de Jong, Henriëtte M. Y.
de Winter, Janneke J. H.
van der Horst‐Bruinsma, Irene E.
van Schaardenburg, Dirk‐Jan
van Gaalen, Floris A.
van Tubergen, Astrid M.
Weel, Angelique E. A. M.
Landewé, Robert B. M.
Baeten, Dominique L. P.
van de Sande, Marleen G. H.
author_facet de Jong, Henriëtte M. Y.
de Winter, Janneke J. H.
van der Horst‐Bruinsma, Irene E.
van Schaardenburg, Dirk‐Jan
van Gaalen, Floris A.
van Tubergen, Astrid M.
Weel, Angelique E. A. M.
Landewé, Robert B. M.
Baeten, Dominique L. P.
van de Sande, Marleen G. H.
author_sort de Jong, Henriëtte M. Y.
collection PubMed
description OBJECTIVE: As first‐degree relatives (FDRs) of HLA–B27–positive patients with axial spondyloarthritis (SpA) have an increased risk of developing axial SpA, the objectives were 1) to evaluate the presence of highly specific imaging features as well as clinical signs of SpA at baseline and after 1 year of follow‐up, and 2) to describe the evolution toward clinical disease within 1 year of follow‐up in a cohort of seemingly healthy FDRs of HLA–B27–positive axial SpA patients. METHODS: The Pre‐SpA cohort is a 5‐year prospective inception cohort of seemingly healthy FDRs of HLA–B27–positive axial SpA patients. Clinical and imaging features were collected and recorded. RESULTS: At baseline, 19% of the FDRs reported inflammatory back pain, 32% current arthralgia, 3% arthritis (ever), 5% enthesitis (ever), and 1% dactylitis (ever), and 3% had an extraarticular manifestation. C‐reactive protein level was elevated in 16%, and erythrocyte sedimentation rate was elevated in 7%. On magnetic resonance imaging (MRI) views of sacroiliac joints, 10% had a Spondyloarthritis Research Consortium of Canada score of ≥2, 4% had a score of ≥5, and 4% had deep lesions. In total, 1% fulfilled the modified New York criteria for radiographic sacroiliitis. Clinical, MRI, and acute phase findings were equally distributed between HLA–B27–positive and –negative FDRs. After 1 year of follow‐up, clinical parameters did not change on the group level, but 6% of the FDRs were clinically diagnosed with axial SpA, of whom 86% were HLA–B27–positive. CONCLUSION: Features associated with SpA or imaging abnormalities were found in up to 32% of seemingly healthy FDRs, with an equal distribution between HLA–B27–positive and –negative FDRs. Progression to clinical axial SpA within 1 year of follow‐up was mainly observed in HLA–B27–positive FDRs.
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spelling pubmed-100872102023-04-12 Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort de Jong, Henriëtte M. Y. de Winter, Janneke J. H. van der Horst‐Bruinsma, Irene E. van Schaardenburg, Dirk‐Jan van Gaalen, Floris A. van Tubergen, Astrid M. Weel, Angelique E. A. M. Landewé, Robert B. M. Baeten, Dominique L. P. van de Sande, Marleen G. H. Arthritis Care Res (Hoboken) Spondyloarthritis OBJECTIVE: As first‐degree relatives (FDRs) of HLA–B27–positive patients with axial spondyloarthritis (SpA) have an increased risk of developing axial SpA, the objectives were 1) to evaluate the presence of highly specific imaging features as well as clinical signs of SpA at baseline and after 1 year of follow‐up, and 2) to describe the evolution toward clinical disease within 1 year of follow‐up in a cohort of seemingly healthy FDRs of HLA–B27–positive axial SpA patients. METHODS: The Pre‐SpA cohort is a 5‐year prospective inception cohort of seemingly healthy FDRs of HLA–B27–positive axial SpA patients. Clinical and imaging features were collected and recorded. RESULTS: At baseline, 19% of the FDRs reported inflammatory back pain, 32% current arthralgia, 3% arthritis (ever), 5% enthesitis (ever), and 1% dactylitis (ever), and 3% had an extraarticular manifestation. C‐reactive protein level was elevated in 16%, and erythrocyte sedimentation rate was elevated in 7%. On magnetic resonance imaging (MRI) views of sacroiliac joints, 10% had a Spondyloarthritis Research Consortium of Canada score of ≥2, 4% had a score of ≥5, and 4% had deep lesions. In total, 1% fulfilled the modified New York criteria for radiographic sacroiliitis. Clinical, MRI, and acute phase findings were equally distributed between HLA–B27–positive and –negative FDRs. After 1 year of follow‐up, clinical parameters did not change on the group level, but 6% of the FDRs were clinically diagnosed with axial SpA, of whom 86% were HLA–B27–positive. CONCLUSION: Features associated with SpA or imaging abnormalities were found in up to 32% of seemingly healthy FDRs, with an equal distribution between HLA–B27–positive and –negative FDRs. Progression to clinical axial SpA within 1 year of follow‐up was mainly observed in HLA–B27–positive FDRs. Wiley Periodicals, Inc. 2022-09-07 2022-12 /pmc/articles/PMC10087210/ /pubmed/34219406 http://dx.doi.org/10.1002/acr.24743 Text en © 2021 The Authors. Arthritis Care & Research published by Wiley Periodicals LLC on behalf of American College of Rheumatology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Spondyloarthritis
de Jong, Henriëtte M. Y.
de Winter, Janneke J. H.
van der Horst‐Bruinsma, Irene E.
van Schaardenburg, Dirk‐Jan
van Gaalen, Floris A.
van Tubergen, Astrid M.
Weel, Angelique E. A. M.
Landewé, Robert B. M.
Baeten, Dominique L. P.
van de Sande, Marleen G. H.
Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort
title Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort
title_full Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort
title_fullStr Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort
title_full_unstemmed Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort
title_short Progression From Subclinical Inflammation to Overt Spondyloarthritis in First‐Degree Relatives of Patients in Association With HLA–B27: The Pre‐Spondyloarthritis Cohort
title_sort progression from subclinical inflammation to overt spondyloarthritis in first‐degree relatives of patients in association with hla–b27: the pre‐spondyloarthritis cohort
topic Spondyloarthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087210/
https://www.ncbi.nlm.nih.gov/pubmed/34219406
http://dx.doi.org/10.1002/acr.24743
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