Cargando…
Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats
BACKGROUND: The objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris. METHODS: Twenty Sprague‐Dawley rats...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087269/ https://www.ncbi.nlm.nih.gov/pubmed/35678251 http://dx.doi.org/10.1002/JPER.22-0091 |
_version_ | 1785022308618862592 |
---|---|
author | Toledano‐Serrabona, Jorge Camps‐Font, Octavi de Moraes, Diogo Pompéu Corte‐Rodríguez, Mario Montes‐Bayón, María Valmaseda‐Castellón, Eduard Gay‐Escoda, Cosme Sánchez‐Garcés, M. Ángeles |
author_facet | Toledano‐Serrabona, Jorge Camps‐Font, Octavi de Moraes, Diogo Pompéu Corte‐Rodríguez, Mario Montes‐Bayón, María Valmaseda‐Castellón, Eduard Gay‐Escoda, Cosme Sánchez‐Garcés, M. Ángeles |
author_sort | Toledano‐Serrabona, Jorge |
collection | PubMed |
description | BACKGROUND: The objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris. METHODS: Twenty Sprague‐Dawley rats were randomly distributed into three groups: an experimental group with a mandibular bone defect filled with metallic debris obtained by implantoplasty; a positive control group; and a negative control group. Thirty days after surgery, the rats were euthanized and perilesional tissue surrounding the mandibular defect was removed, together with the lungs, spleen, liver, and brain. Two blood samples were collected: immediately before surgery and before euthanasia. The perilesional tissue was histologically analyzed using hematoxylin‐eosin staining, and Ti, aluminum, and vanadium ion concentrations in blood and organs were measured by TQ‐ICP‐MS. Descriptive and bivariate analyses of the data were performed. RESULTS: All rats with implanted metal debris showed metal particles and a bone fracture callus on the osseous defect. The metal particles were surrounded by a foreign body reaction characterized by the presence of histiocytes and multinucleated giant cells (MNGCs). The experimental group had a significant higher concentration of Ti ions in all studied organs except lung tissue (p < 0.05). In addition, there were more V ions in the brain in the experimental group (p = 0.008). CONCLUSIONS: Although further studies are required to confirm the clinical relevance of these results, Ti metal particles in the jaw might increase the concentration of metal ions in vital organs and induce a foreign body reaction. |
format | Online Article Text |
id | pubmed-10087269 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100872692023-04-12 Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats Toledano‐Serrabona, Jorge Camps‐Font, Octavi de Moraes, Diogo Pompéu Corte‐Rodríguez, Mario Montes‐Bayón, María Valmaseda‐Castellón, Eduard Gay‐Escoda, Cosme Sánchez‐Garcés, M. Ángeles J Periodontol Translational Periodontology BACKGROUND: The objective of this study was to evaluate the accumulation of ions in blood and organs caused by titanium (Ti) metal particles in a mandibular defect in rats, together with a description of the local reaction of oral tissues to this Ti alloy debris. METHODS: Twenty Sprague‐Dawley rats were randomly distributed into three groups: an experimental group with a mandibular bone defect filled with metallic debris obtained by implantoplasty; a positive control group; and a negative control group. Thirty days after surgery, the rats were euthanized and perilesional tissue surrounding the mandibular defect was removed, together with the lungs, spleen, liver, and brain. Two blood samples were collected: immediately before surgery and before euthanasia. The perilesional tissue was histologically analyzed using hematoxylin‐eosin staining, and Ti, aluminum, and vanadium ion concentrations in blood and organs were measured by TQ‐ICP‐MS. Descriptive and bivariate analyses of the data were performed. RESULTS: All rats with implanted metal debris showed metal particles and a bone fracture callus on the osseous defect. The metal particles were surrounded by a foreign body reaction characterized by the presence of histiocytes and multinucleated giant cells (MNGCs). The experimental group had a significant higher concentration of Ti ions in all studied organs except lung tissue (p < 0.05). In addition, there were more V ions in the brain in the experimental group (p = 0.008). CONCLUSIONS: Although further studies are required to confirm the clinical relevance of these results, Ti metal particles in the jaw might increase the concentration of metal ions in vital organs and induce a foreign body reaction. John Wiley and Sons Inc. 2022-07-28 2023-01 /pmc/articles/PMC10087269/ /pubmed/35678251 http://dx.doi.org/10.1002/JPER.22-0091 Text en © 2022 American Academy of Periodontology. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Translational Periodontology Toledano‐Serrabona, Jorge Camps‐Font, Octavi de Moraes, Diogo Pompéu Corte‐Rodríguez, Mario Montes‐Bayón, María Valmaseda‐Castellón, Eduard Gay‐Escoda, Cosme Sánchez‐Garcés, M. Ángeles Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats |
title | Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats |
title_full | Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats |
title_fullStr | Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats |
title_full_unstemmed | Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats |
title_short | Ion release and local effects of titanium metal particles from dental implants: An experimental study in rats |
title_sort | ion release and local effects of titanium metal particles from dental implants: an experimental study in rats |
topic | Translational Periodontology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087269/ https://www.ncbi.nlm.nih.gov/pubmed/35678251 http://dx.doi.org/10.1002/JPER.22-0091 |
work_keys_str_mv | AT toledanoserrabonajorge ionreleaseandlocaleffectsoftitaniummetalparticlesfromdentalimplantsanexperimentalstudyinrats AT campsfontoctavi ionreleaseandlocaleffectsoftitaniummetalparticlesfromdentalimplantsanexperimentalstudyinrats AT demoraesdiogopompeu ionreleaseandlocaleffectsoftitaniummetalparticlesfromdentalimplantsanexperimentalstudyinrats AT corterodriguezmario ionreleaseandlocaleffectsoftitaniummetalparticlesfromdentalimplantsanexperimentalstudyinrats AT montesbayonmaria ionreleaseandlocaleffectsoftitaniummetalparticlesfromdentalimplantsanexperimentalstudyinrats AT valmasedacastelloneduard ionreleaseandlocaleffectsoftitaniummetalparticlesfromdentalimplantsanexperimentalstudyinrats AT gayescodacosme ionreleaseandlocaleffectsoftitaniummetalparticlesfromdentalimplantsanexperimentalstudyinrats AT sanchezgarcesmangeles ionreleaseandlocaleffectsoftitaniummetalparticlesfromdentalimplantsanexperimentalstudyinrats |