VG161 activates systemic antitumor immunity in pancreatic cancer models as a novel oncolytic herpesvirus expressing multiple immunomodulatory transgenes

The VG161 represents the first recombinant oncolytic herpes simplex virus type 1 carrying multiple synergistic antitumor immuno‐modulating factors. Here, we report its antitumor mechanisms and thus provide firm theoretical foundation for the upcoming clinical application in pancreatic cancer. Genera...

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Detalles Bibliográficos
Autores principales: Shen, Yinan, Song, Wei, Lin, Danni, Zhang, Xiaozhen, Wang, Meng, Li, Yuwei, Yang, Zifan, Guo, Sida, Wang, Zijun, Sheng, Jianpeng, Murad, Yanal, Ding, Jun, Lou, Yufeng, Pan, Xinping, Wu, Zongsong, Zhao, Ronghua, Jia, Weiguo, Bai, Xueli, Liang, Tingbo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087349/
https://www.ncbi.nlm.nih.gov/pubmed/36042555
http://dx.doi.org/10.1002/jmv.28108

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