Emerging technologies and ethics—exogenic chimeric humanized organs

Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cel...

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Detalles Bibliográficos
Autores principales: Garry, Mary G., Caplan, Arthur L., Garry, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Personal Viewpoints
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087366/
https://www.ncbi.nlm.nih.gov/pubmed/36052557
http://dx.doi.org/10.1111/ajt.17188
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author Garry, Mary G.
Caplan, Arthur L.
Garry, Daniel J.
author_facet Garry, Mary G.
Caplan, Arthur L.
Garry, Daniel J.
author_sort Garry, Mary G.
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description Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cell nuclear transfer technology and hiPSCs successfully engineered humanized skeletal muscle in the porcine embryo. As these technologies progress, there are ethical issues that warrant consideration and dialogue.
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spelling pubmed-100873662023-04-12 Emerging technologies and ethics—exogenic chimeric humanized organs Garry, Mary G. Caplan, Arthur L. Garry, Daniel J. Am J Transplant Personal Viewpoints Organ transplantation is limited due to the scarcity of donor organs. In order to expand the supply of organs for transplantation, interspecies chimeras have been examined as a potential future source of humanized organs. Recent studies using gene editing technologies in combination with somatic cell nuclear transfer technology and hiPSCs successfully engineered humanized skeletal muscle in the porcine embryo. As these technologies progress, there are ethical issues that warrant consideration and dialogue. John Wiley and Sons Inc. 2022-09-12 2022-12 /pmc/articles/PMC10087366/ /pubmed/36052557 http://dx.doi.org/10.1111/ajt.17188 Text en © 2022 The Authors. American Journal of Transplantation published by Wiley Periodicals LLC on behalf of The American Society of Transplantation and the American Society of Transplant Surgeons. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Personal Viewpoints
Garry, Mary G.
Caplan, Arthur L.
Garry, Daniel J.
Emerging technologies and ethics—exogenic chimeric humanized organs
title Emerging technologies and ethics—exogenic chimeric humanized organs
title_full Emerging technologies and ethics—exogenic chimeric humanized organs
title_fullStr Emerging technologies and ethics—exogenic chimeric humanized organs
title_full_unstemmed Emerging technologies and ethics—exogenic chimeric humanized organs
title_short Emerging technologies and ethics—exogenic chimeric humanized organs
title_sort emerging technologies and ethics—exogenic chimeric humanized organs
topic Personal Viewpoints
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087366/
https://www.ncbi.nlm.nih.gov/pubmed/36052557
http://dx.doi.org/10.1111/ajt.17188
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