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Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation

Electron beam melting (EBM) has been used to fabricate three‐dimensional (3D) porous Ti‐6Al‐4V surfaces for acetabular cups in total hip arthroplasty. However, there are radiographic concerns regarding poor implant fixation and bone ingrowth around electron beam melted (EBMed) 3D porous cups. We hyp...

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Autores principales: Watanabe, Ryota, Takahashi, Hiroyuki, Matsugaki, Aira, Uemukai, Toru, Kogai, Yasumichi, Imagama, Takashi, Yukata, Kiminori, Nakano, Takayoshi, Sakai, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087424/
https://www.ncbi.nlm.nih.gov/pubmed/36169186
http://dx.doi.org/10.1002/jbm.b.35165
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author Watanabe, Ryota
Takahashi, Hiroyuki
Matsugaki, Aira
Uemukai, Toru
Kogai, Yasumichi
Imagama, Takashi
Yukata, Kiminori
Nakano, Takayoshi
Sakai, Takashi
author_facet Watanabe, Ryota
Takahashi, Hiroyuki
Matsugaki, Aira
Uemukai, Toru
Kogai, Yasumichi
Imagama, Takashi
Yukata, Kiminori
Nakano, Takayoshi
Sakai, Takashi
author_sort Watanabe, Ryota
collection PubMed
description Electron beam melting (EBM) has been used to fabricate three‐dimensional (3D) porous Ti‐6Al‐4V surfaces for acetabular cups in total hip arthroplasty. However, there are radiographic concerns regarding poor implant fixation and bone ingrowth around electron beam melted (EBMed) 3D porous cups. We hypothesize that nano‐hydroxyapatite (nHA) coating can promote bone ingrowth and thus decrease the occurrence of radiolucent lines around EBMed 3D porous cups. This study aimed to investigate the effect of a novel nHA coating on the biological performance of EBMed 3D porous implants in a beagle transcortical model. Low‐porosity (control) and high‐porosity 3D porous Ti‐6Al‐4V implants were manufactured using EBM. Half of the high‐porosity implants were coated with nHA without clogging the 3D pores. Implants were inserted into the femoral diaphysis of the beagles. The beagles were euthanized at 4, 8, and 12 weeks postoperatively, and push‐out testing was performed. Bone ingrowth was evaluated by histological analysis. Although the increase in porosity alone had no effect on biological behavior, the addition of nHA to high‐porosity 3D implants significantly improved early bone fixation and bone ingrowth into the deep region of porous structures compared to low‐porosity implants. This is the first report of a novel nHA coating that improved bone ingrowth into the deeper regions of 3D porous implants, which can prevent the occurrence of radiolucent lines around EBMed 3D porous cups.
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spelling pubmed-100874242023-04-12 Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation Watanabe, Ryota Takahashi, Hiroyuki Matsugaki, Aira Uemukai, Toru Kogai, Yasumichi Imagama, Takashi Yukata, Kiminori Nakano, Takayoshi Sakai, Takashi J Biomed Mater Res B Appl Biomater Research Articles Electron beam melting (EBM) has been used to fabricate three‐dimensional (3D) porous Ti‐6Al‐4V surfaces for acetabular cups in total hip arthroplasty. However, there are radiographic concerns regarding poor implant fixation and bone ingrowth around electron beam melted (EBMed) 3D porous cups. We hypothesize that nano‐hydroxyapatite (nHA) coating can promote bone ingrowth and thus decrease the occurrence of radiolucent lines around EBMed 3D porous cups. This study aimed to investigate the effect of a novel nHA coating on the biological performance of EBMed 3D porous implants in a beagle transcortical model. Low‐porosity (control) and high‐porosity 3D porous Ti‐6Al‐4V implants were manufactured using EBM. Half of the high‐porosity implants were coated with nHA without clogging the 3D pores. Implants were inserted into the femoral diaphysis of the beagles. The beagles were euthanized at 4, 8, and 12 weeks postoperatively, and push‐out testing was performed. Bone ingrowth was evaluated by histological analysis. Although the increase in porosity alone had no effect on biological behavior, the addition of nHA to high‐porosity 3D implants significantly improved early bone fixation and bone ingrowth into the deep region of porous structures compared to low‐porosity implants. This is the first report of a novel nHA coating that improved bone ingrowth into the deeper regions of 3D porous implants, which can prevent the occurrence of radiolucent lines around EBMed 3D porous cups. John Wiley & Sons, Inc. 2022-09-28 2023-02 /pmc/articles/PMC10087424/ /pubmed/36169186 http://dx.doi.org/10.1002/jbm.b.35165 Text en © 2022 The Authors. Journal of Biomedical Materials Research Part B: Applied Biomaterials published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Articles
Watanabe, Ryota
Takahashi, Hiroyuki
Matsugaki, Aira
Uemukai, Toru
Kogai, Yasumichi
Imagama, Takashi
Yukata, Kiminori
Nakano, Takayoshi
Sakai, Takashi
Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation
title Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation
title_full Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation
title_fullStr Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation
title_full_unstemmed Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation
title_short Novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation
title_sort novel nano‐hydroxyapatite coating of additively manufactured three‐dimensional porous implants improves bone ingrowth and initial fixation
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087424/
https://www.ncbi.nlm.nih.gov/pubmed/36169186
http://dx.doi.org/10.1002/jbm.b.35165
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