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Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care

BACKGROUND AND AIMS: Significant barriers exist with hepatitis B (HBV) case detection and effective linkage to care (LTC). The emergency department (ED) is a unique healthcare interaction where hepatitis screening and LTC could be achieved. We examined the efficacy and utility of automated ED HBV sc...

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Autores principales: Jacob, Rachael, Prince, David S., Pipicella, Joseph L., Nguyen, Angela, Bagatella, Melissa, Alvaro, Frank, Maley, Michael, Foo, Hong, Middleton, Paul, Kayes, Tahrima, DiGirolamo, Julia, Davison, Scott A., Levy, Miriam T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087472/
https://www.ncbi.nlm.nih.gov/pubmed/36050826
http://dx.doi.org/10.1111/liv.15414
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author Jacob, Rachael
Prince, David S.
Pipicella, Joseph L.
Nguyen, Angela
Bagatella, Melissa
Alvaro, Frank
Maley, Michael
Foo, Hong
Middleton, Paul
Kayes, Tahrima
DiGirolamo, Julia
Davison, Scott A.
Levy, Miriam T.
author_facet Jacob, Rachael
Prince, David S.
Pipicella, Joseph L.
Nguyen, Angela
Bagatella, Melissa
Alvaro, Frank
Maley, Michael
Foo, Hong
Middleton, Paul
Kayes, Tahrima
DiGirolamo, Julia
Davison, Scott A.
Levy, Miriam T.
author_sort Jacob, Rachael
collection PubMed
description BACKGROUND AND AIMS: Significant barriers exist with hepatitis B (HBV) case detection and effective linkage to care (LTC). The emergency department (ED) is a unique healthcare interaction where hepatitis screening and LTC could be achieved. We examined the efficacy and utility of automated ED HBV screening for Overseas Born (OB) patients. METHODS: A novel‐automated hepatitis screening service “SEARCH” (Screening Emergency Admissions at Risk of Chronic Hepatitis) was piloted at a metropolitan hospital. A retrospective and comparative analysis of hepatitis testing during the SEARCH pilot compared to a period of routine testing was conducted. RESULTS: During the SEARCH pilot, 4778 OB patients were tested for HBV (86% of eligible patient presentations), compared with 1.9% of eligible patients during a control period of clinician‐initiated testing. SEARCH detected 108 (2.3%) hepatitis B surface antigen positive patients including 20 (19%) in whom the diagnosis was new. Among 88 patients with known HBV, 57% were receiving medical care, 33% had become lost to follow‐up and 10% had never received HBV care. Overall, 30/88 (34%) patients with known HBV were receiving complete guideline‐based care prior to re‐engagement via SEARCH. Following SEARCH, LTC was successful achieved in 48/58 (83%) unlinked patients and 19 patients were commenced on anti‐viral therapy. New diagnoses of cirrhosis and hepatocellular carcinoma were made in five and one patient(s) respectively. CONCLUSIONS: Automated ED screening of OB patients is effective in HBV diagnosis, re‐diagnosis and LTC. Prior to SEARCH, the majority of patients were not receiving guideline‐based care.
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spelling pubmed-100874722023-04-12 Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care Jacob, Rachael Prince, David S. Pipicella, Joseph L. Nguyen, Angela Bagatella, Melissa Alvaro, Frank Maley, Michael Foo, Hong Middleton, Paul Kayes, Tahrima DiGirolamo, Julia Davison, Scott A. Levy, Miriam T. Liver Int Liver Disease and Public Health BACKGROUND AND AIMS: Significant barriers exist with hepatitis B (HBV) case detection and effective linkage to care (LTC). The emergency department (ED) is a unique healthcare interaction where hepatitis screening and LTC could be achieved. We examined the efficacy and utility of automated ED HBV screening for Overseas Born (OB) patients. METHODS: A novel‐automated hepatitis screening service “SEARCH” (Screening Emergency Admissions at Risk of Chronic Hepatitis) was piloted at a metropolitan hospital. A retrospective and comparative analysis of hepatitis testing during the SEARCH pilot compared to a period of routine testing was conducted. RESULTS: During the SEARCH pilot, 4778 OB patients were tested for HBV (86% of eligible patient presentations), compared with 1.9% of eligible patients during a control period of clinician‐initiated testing. SEARCH detected 108 (2.3%) hepatitis B surface antigen positive patients including 20 (19%) in whom the diagnosis was new. Among 88 patients with known HBV, 57% were receiving medical care, 33% had become lost to follow‐up and 10% had never received HBV care. Overall, 30/88 (34%) patients with known HBV were receiving complete guideline‐based care prior to re‐engagement via SEARCH. Following SEARCH, LTC was successful achieved in 48/58 (83%) unlinked patients and 19 patients were commenced on anti‐viral therapy. New diagnoses of cirrhosis and hepatocellular carcinoma were made in five and one patient(s) respectively. CONCLUSIONS: Automated ED screening of OB patients is effective in HBV diagnosis, re‐diagnosis and LTC. Prior to SEARCH, the majority of patients were not receiving guideline‐based care. John Wiley and Sons Inc. 2022-09-14 2023-01 /pmc/articles/PMC10087472/ /pubmed/36050826 http://dx.doi.org/10.1111/liv.15414 Text en © 2022 The Authors. Liver International published by John Wiley & Sons Ltd. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Liver Disease and Public Health
Jacob, Rachael
Prince, David S.
Pipicella, Joseph L.
Nguyen, Angela
Bagatella, Melissa
Alvaro, Frank
Maley, Michael
Foo, Hong
Middleton, Paul
Kayes, Tahrima
DiGirolamo, Julia
Davison, Scott A.
Levy, Miriam T.
Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care
title Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care
title_full Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care
title_fullStr Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care
title_full_unstemmed Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care
title_short Routine screening of emergency admissions at risk of chronic hepatitis (SEARCH) identifies and links hepatitis B cases to care
title_sort routine screening of emergency admissions at risk of chronic hepatitis (search) identifies and links hepatitis b cases to care
topic Liver Disease and Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087472/
https://www.ncbi.nlm.nih.gov/pubmed/36050826
http://dx.doi.org/10.1111/liv.15414
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