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Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation
OBJECTIVE: To assess the correlation between standard laboratory indicators at admission and severe maternal complications due to placental abruption (PA) with intrauterine fetal death (IUFD) after 24 weeks. METHODS: Retrospective study in three French tertiary referral hospitals. Correlation of lab...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087485/ https://www.ncbi.nlm.nih.gov/pubmed/35986606 http://dx.doi.org/10.1002/ijgo.14417 |
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author | Atallah, Anthony Piccin, Gaelle Dubernard, Gil Abdul‐Hay, Marie Jo Cortet, Marion Huissoud, Cyril |
author_facet | Atallah, Anthony Piccin, Gaelle Dubernard, Gil Abdul‐Hay, Marie Jo Cortet, Marion Huissoud, Cyril |
author_sort | Atallah, Anthony |
collection | PubMed |
description | OBJECTIVE: To assess the correlation between standard laboratory indicators at admission and severe maternal complications due to placental abruption (PA) with intrauterine fetal death (IUFD) after 24 weeks. METHODS: Retrospective study in three French tertiary referral hospitals. Correlation of laboratory indicators at admission (platelet count, prothrombin, activated partial thromboplastin time, fibrinogen) and severe maternal complications (massive transfusion, multiple organ failure, hysterectomy, or maternal deaths) in patients with PA and IUFD. RESULTS: Over 12 years, we identified 27/344 (7.8%) pregnant women presenting PA with IUFD. No patient had coagulopathy at admission. Fifteen individuals (55.5%) underwent delivery by cesarean section before or during labor. Fifteen individuals (55.5%) presented severe complications, and 17/27 (63%) lost more than 1 L of blood during delivery. Fibrinogen level was shown to be the laboratory indicator most correlated with severe complications (r = −0.52, P = 0.01). The receiver operating characteristic curve of fibrinogen less than 1.9 g/L in the prediction of severe complications (area under the curve = 0.80, 95% confidence interval [CI] 0.54–0.97) showed both a sensitivity and specificity of 83% (95% CI 54%–96%). CONCLUSIONS: In cases of IUFD with PA, fibrinogen levels at admission had a prognostic value for the prediction of severe maternal complications. |
format | Online Article Text |
id | pubmed-10087485 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100874852023-04-12 Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation Atallah, Anthony Piccin, Gaelle Dubernard, Gil Abdul‐Hay, Marie Jo Cortet, Marion Huissoud, Cyril Int J Gynaecol Obstet Clinical Articles OBJECTIVE: To assess the correlation between standard laboratory indicators at admission and severe maternal complications due to placental abruption (PA) with intrauterine fetal death (IUFD) after 24 weeks. METHODS: Retrospective study in three French tertiary referral hospitals. Correlation of laboratory indicators at admission (platelet count, prothrombin, activated partial thromboplastin time, fibrinogen) and severe maternal complications (massive transfusion, multiple organ failure, hysterectomy, or maternal deaths) in patients with PA and IUFD. RESULTS: Over 12 years, we identified 27/344 (7.8%) pregnant women presenting PA with IUFD. No patient had coagulopathy at admission. Fifteen individuals (55.5%) underwent delivery by cesarean section before or during labor. Fifteen individuals (55.5%) presented severe complications, and 17/27 (63%) lost more than 1 L of blood during delivery. Fibrinogen level was shown to be the laboratory indicator most correlated with severe complications (r = −0.52, P = 0.01). The receiver operating characteristic curve of fibrinogen less than 1.9 g/L in the prediction of severe complications (area under the curve = 0.80, 95% confidence interval [CI] 0.54–0.97) showed both a sensitivity and specificity of 83% (95% CI 54%–96%). CONCLUSIONS: In cases of IUFD with PA, fibrinogen levels at admission had a prognostic value for the prediction of severe maternal complications. John Wiley and Sons Inc. 2022-09-03 2023-03 /pmc/articles/PMC10087485/ /pubmed/35986606 http://dx.doi.org/10.1002/ijgo.14417 Text en © 2022 The Authors. International Journal of Gynecology & Obstetrics published by John Wiley & Sons Ltd on behalf of International Federation of Gynecology and Obstetrics. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Clinical Articles Atallah, Anthony Piccin, Gaelle Dubernard, Gil Abdul‐Hay, Marie Jo Cortet, Marion Huissoud, Cyril Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation |
title | Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation |
title_full | Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation |
title_fullStr | Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation |
title_full_unstemmed | Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation |
title_short | Fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation |
title_sort | fibrinogen for the prediction of severe maternal complications in placental abruption with fetal death after 24 weeks of gestation |
topic | Clinical Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087485/ https://www.ncbi.nlm.nih.gov/pubmed/35986606 http://dx.doi.org/10.1002/ijgo.14417 |
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