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Prostate cancer aggressiveness and financial toxicity among prostate cancer patients
INTRODUCTION: Financial toxicity (FT) is a growing concern among cancer survivors that adversely affects the quality of life and survival. Individuals diagnosed with aggressive cancers are often at a greater risk of experiencing FT. The objectives of this study were to estimate FT among prostate can...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087487/ https://www.ncbi.nlm.nih.gov/pubmed/36063402 http://dx.doi.org/10.1002/pros.24434 |
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author | KC, Madhav Oral, Evrim Rung, Ariane L. Trapido, Edward Rozek, Laura S. Fontham, Elizabeth T. H. Bensen, Jeannette T. Farnan, Laura Steck, Susan E. Song, Lixin Mohler, James L. Khan, Saira Vohra, Sanah Peters, Edward S. |
author_facet | KC, Madhav Oral, Evrim Rung, Ariane L. Trapido, Edward Rozek, Laura S. Fontham, Elizabeth T. H. Bensen, Jeannette T. Farnan, Laura Steck, Susan E. Song, Lixin Mohler, James L. Khan, Saira Vohra, Sanah Peters, Edward S. |
author_sort | KC, Madhav |
collection | PubMed |
description | INTRODUCTION: Financial toxicity (FT) is a growing concern among cancer survivors that adversely affects the quality of life and survival. Individuals diagnosed with aggressive cancers are often at a greater risk of experiencing FT. The objectives of this study were to estimate FT among prostate cancer (PCa) survivors after 10−15 years of diagnosis, assess the relationship between PCa aggressiveness at diagnosis and FT, and examine whether current cancer treatment status mediates the relationship between PCa aggressiveness and FT. METHODS: PCa patients enrolled in the North Carolina‐Louisiana Prostate Cancer Project (PCaP) were recontacted for long‐term follow‐up. The prevalence of FT in the PCaP cohort was estimated. FT was estimated using the COmprehensive Score for Financial Toxicity, a validated measure of FT. The direct effect of PCa aggressiveness and an indirect effect through current cancer treatment on FT was examined using causal mediation analysis. RESULTS: More than one‐third of PCa patients reported experiencing FT. PCa aggressiveness was significantly independently associated with high FT; high aggressive PCa at diagnosis had more than twice the risk of experiencing FT than those with low or intermediate aggressive PCa (adjusted odds ratio [aOR] = 2.13, 95% CI = 1.14−3.96). The proportion of the effect of PCa aggressiveness on FT, mediated by treatment status, was 10%, however, the adjusted odds ratio did not indicate significant evidence of mediation by treatment status (aOR = 1.05, 95% CI = 0.95−1.20). CONCLUSIONS: Aggressive PCa was associated with high FT. Future studies should collect more information about the characteristics of men with high FT and identify additional risk factors of FT. |
format | Online Article Text |
id | pubmed-10087487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-100874872023-04-12 Prostate cancer aggressiveness and financial toxicity among prostate cancer patients KC, Madhav Oral, Evrim Rung, Ariane L. Trapido, Edward Rozek, Laura S. Fontham, Elizabeth T. H. Bensen, Jeannette T. Farnan, Laura Steck, Susan E. Song, Lixin Mohler, James L. Khan, Saira Vohra, Sanah Peters, Edward S. Prostate Original Articles INTRODUCTION: Financial toxicity (FT) is a growing concern among cancer survivors that adversely affects the quality of life and survival. Individuals diagnosed with aggressive cancers are often at a greater risk of experiencing FT. The objectives of this study were to estimate FT among prostate cancer (PCa) survivors after 10−15 years of diagnosis, assess the relationship between PCa aggressiveness at diagnosis and FT, and examine whether current cancer treatment status mediates the relationship between PCa aggressiveness and FT. METHODS: PCa patients enrolled in the North Carolina‐Louisiana Prostate Cancer Project (PCaP) were recontacted for long‐term follow‐up. The prevalence of FT in the PCaP cohort was estimated. FT was estimated using the COmprehensive Score for Financial Toxicity, a validated measure of FT. The direct effect of PCa aggressiveness and an indirect effect through current cancer treatment on FT was examined using causal mediation analysis. RESULTS: More than one‐third of PCa patients reported experiencing FT. PCa aggressiveness was significantly independently associated with high FT; high aggressive PCa at diagnosis had more than twice the risk of experiencing FT than those with low or intermediate aggressive PCa (adjusted odds ratio [aOR] = 2.13, 95% CI = 1.14−3.96). The proportion of the effect of PCa aggressiveness on FT, mediated by treatment status, was 10%, however, the adjusted odds ratio did not indicate significant evidence of mediation by treatment status (aOR = 1.05, 95% CI = 0.95−1.20). CONCLUSIONS: Aggressive PCa was associated with high FT. Future studies should collect more information about the characteristics of men with high FT and identify additional risk factors of FT. John Wiley and Sons Inc. 2022-09-05 2023-01-01 /pmc/articles/PMC10087487/ /pubmed/36063402 http://dx.doi.org/10.1002/pros.24434 Text en © 2022 The Authors. The Prostate published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes. |
spellingShingle | Original Articles KC, Madhav Oral, Evrim Rung, Ariane L. Trapido, Edward Rozek, Laura S. Fontham, Elizabeth T. H. Bensen, Jeannette T. Farnan, Laura Steck, Susan E. Song, Lixin Mohler, James L. Khan, Saira Vohra, Sanah Peters, Edward S. Prostate cancer aggressiveness and financial toxicity among prostate cancer patients |
title | Prostate cancer aggressiveness and financial toxicity among prostate cancer patients |
title_full | Prostate cancer aggressiveness and financial toxicity among prostate cancer patients |
title_fullStr | Prostate cancer aggressiveness and financial toxicity among prostate cancer patients |
title_full_unstemmed | Prostate cancer aggressiveness and financial toxicity among prostate cancer patients |
title_short | Prostate cancer aggressiveness and financial toxicity among prostate cancer patients |
title_sort | prostate cancer aggressiveness and financial toxicity among prostate cancer patients |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087487/ https://www.ncbi.nlm.nih.gov/pubmed/36063402 http://dx.doi.org/10.1002/pros.24434 |
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