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Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation

BACKGROUND: Behavioural and language difficulties co‐occur in multiple neurodevelopmental conditions. Our understanding of these problems has arguably been slowed by an overreliance on study designs that compare diagnostic groups and fail to capture the overlap across different neurodevelopmental di...

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Autores principales: Mareva, Silvana, Akarca, Danyal, Holmes, Joni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087495/
https://www.ncbi.nlm.nih.gov/pubmed/36127748
http://dx.doi.org/10.1111/jcpp.13685
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author Mareva, Silvana
Akarca, Danyal
Holmes, Joni
author_facet Mareva, Silvana
Akarca, Danyal
Holmes, Joni
author_sort Mareva, Silvana
collection PubMed
description BACKGROUND: Behavioural and language difficulties co‐occur in multiple neurodevelopmental conditions. Our understanding of these problems has arguably been slowed by an overreliance on study designs that compare diagnostic groups and fail to capture the overlap across different neurodevelopmental disorders and the heterogeneity within them. METHODS: We recruited a large transdiagnostic cohort of children with complex needs (N = 805) to identify distinct subgroups of children with common profiles of behavioural and language strengths and difficulties. We then investigated whether and how these data‐driven groupings could be distinguished from a comparison sample (N = 158) on measures of academic and socioemotional functioning and patterns of global and local white matter connectome organisation. Academic skills were assessed via standardised measures of reading and maths. Socioemotional functioning was captured by the parent‐rated version of the Strengths and Difficulties Questionnaire. RESULTS: We identified three distinct subgroups of children, each with different levels of difficulties in structural language, pragmatic communication, and hot and cool executive functions. All three subgroups struggled with academic and socioemotional skills relative to the comparison sample, potentially representing three alternative but related developmental pathways to difficulties in these areas. The children with the weakest language skills had the most widespread difficulties with learning, whereas those with more pronounced difficulties with hot executive skills experienced the most severe difficulties in the socioemotional domain. Each data‐driven subgroup could be distinguished from the comparison sample based on both shared and subgroup‐unique patterns of neural white matter organisation. Children with the most pronounced deficits in language, cool executive, or hot executive function were differentiated from the comparison sample by altered connectivity in predominantly thalamocortical, temporal–parietal‐occipital, and frontostriatal circuits, respectively. CONCLUSIONS: These findings advance our understanding of commonly co‐morbid behavioural and language problems and their relationship to behavioural outcomes and neurobiological substrates.
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spelling pubmed-100874952023-04-12 Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation Mareva, Silvana Akarca, Danyal Holmes, Joni J Child Psychol Psychiatry Original Articles BACKGROUND: Behavioural and language difficulties co‐occur in multiple neurodevelopmental conditions. Our understanding of these problems has arguably been slowed by an overreliance on study designs that compare diagnostic groups and fail to capture the overlap across different neurodevelopmental disorders and the heterogeneity within them. METHODS: We recruited a large transdiagnostic cohort of children with complex needs (N = 805) to identify distinct subgroups of children with common profiles of behavioural and language strengths and difficulties. We then investigated whether and how these data‐driven groupings could be distinguished from a comparison sample (N = 158) on measures of academic and socioemotional functioning and patterns of global and local white matter connectome organisation. Academic skills were assessed via standardised measures of reading and maths. Socioemotional functioning was captured by the parent‐rated version of the Strengths and Difficulties Questionnaire. RESULTS: We identified three distinct subgroups of children, each with different levels of difficulties in structural language, pragmatic communication, and hot and cool executive functions. All three subgroups struggled with academic and socioemotional skills relative to the comparison sample, potentially representing three alternative but related developmental pathways to difficulties in these areas. The children with the weakest language skills had the most widespread difficulties with learning, whereas those with more pronounced difficulties with hot executive skills experienced the most severe difficulties in the socioemotional domain. Each data‐driven subgroup could be distinguished from the comparison sample based on both shared and subgroup‐unique patterns of neural white matter organisation. Children with the most pronounced deficits in language, cool executive, or hot executive function were differentiated from the comparison sample by altered connectivity in predominantly thalamocortical, temporal–parietal‐occipital, and frontostriatal circuits, respectively. CONCLUSIONS: These findings advance our understanding of commonly co‐morbid behavioural and language problems and their relationship to behavioural outcomes and neurobiological substrates. John Wiley and Sons Inc. 2022-09-20 2023-02 /pmc/articles/PMC10087495/ /pubmed/36127748 http://dx.doi.org/10.1111/jcpp.13685 Text en © 2022 The Authors. Journal of Child Psychology and Psychiatry published by John Wiley & Sons Ltd on behalf of Association for Child and Adolescent Mental Health. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Mareva, Silvana
Akarca, Danyal
Holmes, Joni
Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation
title Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation
title_full Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation
title_fullStr Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation
title_full_unstemmed Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation
title_short Transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation
title_sort transdiagnostic profiles of behaviour and communication relate to academic and socioemotional functioning and neural white matter organisation
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087495/
https://www.ncbi.nlm.nih.gov/pubmed/36127748
http://dx.doi.org/10.1111/jcpp.13685
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