Enzyme kinetics by GH7 cellobiohydrolases on chromogenic substrates is dictated by non‐productive binding: insights from crystal structures and MD simulation

Cellobiohydrolases (CBHs) in the glycoside hydrolase family 7 (GH7) (EC3.2.1.176) are the major cellulose degrading enzymes both in industrial settings and in the context of carbon cycling in nature. Small carbohydrate conjugates such as p‐nitrophenyl‐β‐d‐cellobioside (pNPC), p‐nitrophenyl‐β‐d‐lacto...

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Detalles Bibliográficos
Autores principales: Haataja, Topi, Gado, Japheth E., Nutt, Anu, Anderson, Nolan T., Nilsson, Mikael, Momeni, Majid Haddad, Isaksson, Roland, Väljamäe, Priit, Johansson, Gunnar, Payne, Christina M., Ståhlberg, Jerry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087753/
https://www.ncbi.nlm.nih.gov/pubmed/35997626
http://dx.doi.org/10.1111/febs.16602

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