Cargando…

Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study

The 24-h activity cycle (24HAC) is a new paradigm for studying activity behaviors in relation to health outcomes. This approach inherently captures the interrelatedness of the daily time spent in physical activity (PA), sedentary behavior (SB), and sleep. We describe three popular approaches for mod...

Descripción completa

Detalles Bibliográficos
Autores principales: Wu, Yinxiang, Rosenberg, Dori E., Greenwood-Hickman, Mikael Anne, McCurry, Susan M., Proust-Lima, Cécile, Nelson, Jennifer C., Crane, Paul K., LaCroix, Andrea Z., Larson, Eric B., Shaw, Pamela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087899/
https://www.ncbi.nlm.nih.gov/pubmed/37057157
http://dx.doi.org/10.3389/fpsyg.2023.1083344
_version_ 1785022454849077248
author Wu, Yinxiang
Rosenberg, Dori E.
Greenwood-Hickman, Mikael Anne
McCurry, Susan M.
Proust-Lima, Cécile
Nelson, Jennifer C.
Crane, Paul K.
LaCroix, Andrea Z.
Larson, Eric B.
Shaw, Pamela A.
author_facet Wu, Yinxiang
Rosenberg, Dori E.
Greenwood-Hickman, Mikael Anne
McCurry, Susan M.
Proust-Lima, Cécile
Nelson, Jennifer C.
Crane, Paul K.
LaCroix, Andrea Z.
Larson, Eric B.
Shaw, Pamela A.
author_sort Wu, Yinxiang
collection PubMed
description The 24-h activity cycle (24HAC) is a new paradigm for studying activity behaviors in relation to health outcomes. This approach inherently captures the interrelatedness of the daily time spent in physical activity (PA), sedentary behavior (SB), and sleep. We describe three popular approaches for modeling outcome associations with the 24HAC exposure. We apply these approaches to assess an association with a cognitive outcome in a cohort of older adults, discuss statistical challenges, and provide guidance on interpretation and selecting an appropriate approach. We compare the use of the isotemporal substitution model (ISM), compositional data analysis (CoDA), and latent profile analysis (LPA) to analyze 24HAC. We illustrate each method by exploring cross-sectional associations with cognition in 1,034 older adults (Mean age = 77; Age range = 65–100; 55.8% female; 90% White) who were part of the Adult Changes in Thought (ACT) Activity Monitoring (ACT-AM) sub-study. PA and SB were assessed with thigh-worn activPAL accelerometers for 7-days. For each method, we fit a multivariable regression model to examine the cross-sectional association between the 24HAC and Cognitive Abilities Screening Instrument item response theory (CASI-IRT) score, adjusting for baseline characteristics. We highlight differences in assumptions and the scientific questions addressable by each approach. ISM is easiest to apply and interpret; however, the typical ISM assumes a linear association. CoDA uses an isometric log-ratio transformation to directly model the compositional exposure but can be more challenging to apply and interpret. LPA can serve as an exploratory analysis tool to classify individuals into groups with similar time-use patterns. Inference on associations of latent profiles with health outcomes need to account for the uncertainty of the LPA classifications, which is often ignored. Analyses using the three methods did not suggest that less time spent on SB and more in PA was associated with better cognitive function. The three standard analytical approaches for 24HAC each have advantages and limitations, and selection of the most appropriate method should be guided by the scientific questions of interest and applicability of each model’s assumptions. Further research is needed into the health implications of the distinct 24HAC patterns identified in this cohort.
format Online
Article
Text
id pubmed-10087899
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-100878992023-04-12 Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study Wu, Yinxiang Rosenberg, Dori E. Greenwood-Hickman, Mikael Anne McCurry, Susan M. Proust-Lima, Cécile Nelson, Jennifer C. Crane, Paul K. LaCroix, Andrea Z. Larson, Eric B. Shaw, Pamela A. Front Psychol Psychology The 24-h activity cycle (24HAC) is a new paradigm for studying activity behaviors in relation to health outcomes. This approach inherently captures the interrelatedness of the daily time spent in physical activity (PA), sedentary behavior (SB), and sleep. We describe three popular approaches for modeling outcome associations with the 24HAC exposure. We apply these approaches to assess an association with a cognitive outcome in a cohort of older adults, discuss statistical challenges, and provide guidance on interpretation and selecting an appropriate approach. We compare the use of the isotemporal substitution model (ISM), compositional data analysis (CoDA), and latent profile analysis (LPA) to analyze 24HAC. We illustrate each method by exploring cross-sectional associations with cognition in 1,034 older adults (Mean age = 77; Age range = 65–100; 55.8% female; 90% White) who were part of the Adult Changes in Thought (ACT) Activity Monitoring (ACT-AM) sub-study. PA and SB were assessed with thigh-worn activPAL accelerometers for 7-days. For each method, we fit a multivariable regression model to examine the cross-sectional association between the 24HAC and Cognitive Abilities Screening Instrument item response theory (CASI-IRT) score, adjusting for baseline characteristics. We highlight differences in assumptions and the scientific questions addressable by each approach. ISM is easiest to apply and interpret; however, the typical ISM assumes a linear association. CoDA uses an isometric log-ratio transformation to directly model the compositional exposure but can be more challenging to apply and interpret. LPA can serve as an exploratory analysis tool to classify individuals into groups with similar time-use patterns. Inference on associations of latent profiles with health outcomes need to account for the uncertainty of the LPA classifications, which is often ignored. Analyses using the three methods did not suggest that less time spent on SB and more in PA was associated with better cognitive function. The three standard analytical approaches for 24HAC each have advantages and limitations, and selection of the most appropriate method should be guided by the scientific questions of interest and applicability of each model’s assumptions. Further research is needed into the health implications of the distinct 24HAC patterns identified in this cohort. Frontiers Media S.A. 2023-03-27 /pmc/articles/PMC10087899/ /pubmed/37057157 http://dx.doi.org/10.3389/fpsyg.2023.1083344 Text en Copyright © 2023 Wu, Rosenberg, Greenwood-Hickman, McCurry, Proust-Lima, Nelson, Crane, LaCroix, Larson and Shaw. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Psychology
Wu, Yinxiang
Rosenberg, Dori E.
Greenwood-Hickman, Mikael Anne
McCurry, Susan M.
Proust-Lima, Cécile
Nelson, Jennifer C.
Crane, Paul K.
LaCroix, Andrea Z.
Larson, Eric B.
Shaw, Pamela A.
Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study
title Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study
title_full Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study
title_fullStr Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study
title_full_unstemmed Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study
title_short Analysis of the 24-h activity cycle: An illustration examining the association with cognitive function in the Adult Changes in Thought study
title_sort analysis of the 24-h activity cycle: an illustration examining the association with cognitive function in the adult changes in thought study
topic Psychology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087899/
https://www.ncbi.nlm.nih.gov/pubmed/37057157
http://dx.doi.org/10.3389/fpsyg.2023.1083344
work_keys_str_mv AT wuyinxiang analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT rosenbergdorie analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT greenwoodhickmanmikaelanne analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT mccurrysusanm analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT proustlimacecile analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT nelsonjenniferc analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT cranepaulk analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT lacroixandreaz analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT larsonericb analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy
AT shawpamelaa analysisofthe24hactivitycycleanillustrationexaminingtheassociationwithcognitivefunctionintheadultchangesinthoughtstudy