Sphingosine 1‐phosphate attenuates neuronal dysfunction induced by amyloid‐β oligomers through endocytic internalization of NMDA receptors

Soluble oligomers arising from the aggregation of the amyloid beta peptide (Aβ) have been identified as the main pathogenic agents in Alzheimer's disease (AD). Prefibrillar oligomers of the 42‐residue form of Aβ (Aβ(42)O) show membrane‐binding capacity and trigger the disruption of Ca(2+) homeo...

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Detalles Bibliográficos
Autores principales: Bigi, Alessandra, Cascella, Roberta, Fani, Giulia, Bernacchioni, Caterina, Cencetti, Francesca, Bruni, Paola, Chiti, Fabrizio, Donati, Chiara, Cecchi, Cristina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087929/
https://www.ncbi.nlm.nih.gov/pubmed/35851748
http://dx.doi.org/10.1111/febs.16579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087929/
https://www.ncbi.nlm.nih.gov/pubmed/35851748
http://dx.doi.org/10.1111/febs.16579

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