Cargando…

Sphingosine 1‐phosphate attenuates neuronal dysfunction induced by amyloid‐β oligomers through endocytic internalization of NMDA receptors

Soluble oligomers arising from the aggregation of the amyloid beta peptide (Aβ) have been identified as the main pathogenic agents in Alzheimer's disease (AD). Prefibrillar oligomers of the 42‐residue form of Aβ (Aβ(42)O) show membrane‐binding capacity and trigger the disruption of Ca(2+) homeo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bigi, Alessandra, Cascella, Roberta, Fani, Giulia, Bernacchioni, Caterina, Cencetti, Francesca, Bruni, Paola, Chiti, Fabrizio, Donati, Chiara, Cecchi, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087929/ https://www.ncbi.nlm.nih.gov/pubmed/35851748 http://dx.doi.org/10.1111/febs.16579

Ejemplares similares

Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation
por: Bernacchioni, Caterina, et al.
Publicado: (2012)

Aβ Oligomers Dysregulate Calcium Homeostasis by Mechanosensitive Activation of AMPA and NMDA Receptors
por: Fani, Giulia, et al.
Publicado: (2021)

Role of Sphingosine 1-Phosphate Signalling Axis in Muscle Atrophy Induced by TNFα in C2C12 Myotubes
por: Bernacchioni, Caterina, et al.
Publicado: (2021)

Transforming Growth Factor-β1 Induces Transdifferentiation of Myoblasts into Myofibroblasts via Up-Regulation of Sphingosine Kinase-1/S1P(3) Axis
por: Cencetti, Francesca, et al.
Publicado: (2010)

Sphingosine 1-Phosphate Induces Differentiation of Mesoangioblasts towards Smooth Muscle. A Role for GATA6
por: Donati, Chiara, et al.
Publicado: (2011)

NMR metabolomics highlights sphingosine kinase‐1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells
por: Bernacchioni, Caterina, et al.
Publicado: (2017)

Sphingosine 1-phosphate axis: a new leader actor in skeletal muscle biology
por: Donati, Chiara, et al.
Publicado: (2013)

Partial Failure of Proteostasis Systems Counteracting TDP-43 Aggregates in Neurodegenerative Diseases
por: Cascella, Roberta, et al.
Publicado: (2019)

Misfolded protein oligomers induce an increase of intracellular Ca(2+) causing an escalation of reactive oxidative species
por: Fani, Giulia, et al.
Publicado: (2022)

Ceramide 1-phosphate stimulates proliferation of C2C12 myoblasts
por: Gangoiti, Patricia, et al.
Publicado: (2012)

Sphingosine 1-phosphate signaling pathway in inner ear biology. New therapeutic strategies for hearing loss?
por: Romero-Guevara, Ricardo, et al.
Publicado: (2015)

Lysophosphatidic Acid Signaling Axis Mediates Ceramide 1-Phosphate-Induced Proliferation of C2C12 Myoblasts
por: Bernacchioni, Caterina, et al.
Publicado: (2018)

The TRPV1 Receptor Is Up-Regulated by Sphingosine 1-Phosphate and Is Implicated in the Anandamide-Dependent Regulation of Mitochondrial Activity in C2C12 Myoblasts
por: Standoli, Sara, et al.
Publicado: (2022)

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases
por: Evangelisti, Elisa, et al.
Publicado: (2016)

α-Synuclein oligomers and fibrils: partners in crime in synucleinopathies
por: Bigi, Alessandra, et al.
Publicado: (2023)

Mechanosensitivity of N-methyl-D-aspartate receptors (NMDAR) is the key through which amyloid beta oligomers activate them
por: Fani, Giulia, et al.
Publicado: (2021)

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
por: Cascella, Roberta, et al.
Publicado: (2021)

Effects of oligomer toxicity, fibril toxicity and fibril spreading in synucleinopathies
por: Cascella, Roberta, et al.
Publicado: (2022)

Nanoscopic insights into the surface conformation of neurotoxic amyloid β oligomers
por: Banchelli, Martina, et al.
Publicado: (2020)

A(2)(B) Adenosine Receptors and Sphingosine 1-Phosphate Signaling Cross-Talk in Oligodendrogliogenesis
por: Coppi, Elisabetta, et al.
Publicado: (2021)

Characterization of Pairs of Toxic and Nontoxic Misfolded Protein Oligomers Elucidates the Structural Determinants of Oligomer Toxicity in Protein Misfolding Diseases
por: Limbocker, Ryan, et al.
Publicado: (2023)

Exploring the Release of Toxic Oligomers from α-Synuclein Fibrils with Antibodies and STED Microscopy
por: Bigi, Alessandra, et al.
Publicado: (2021)

Soluble Prion Peptide 107–120 Protects Neuroblastoma SH-SY5Y Cells against Oligomers Associated with Alzheimer’s Disease
por: Rezvani Boroujeni, Elham, et al.
Publicado: (2020)

Transthyretin Inhibits Primary and Secondary Nucleations of Amyloid-β Peptide Aggregation and Reduces the Toxicity of Its Oligomers
por: Ghadami, Seyyed Abolghasem, et al.
Publicado: (2020)

Interaction of toxic and non-toxic HypF-N oligomers with lipid bilayers investigated at high resolution with atomic force microscopy
por: Oropesa-Nuñez, Reinier, et al.
Publicado: (2016)

A comparison of the biochemical modifications caused by toxic and non-toxic protein oligomers in cells
por: Zampagni, Mariagioia, et al.
Publicado: (2011)

Squalamine and Its Derivatives Modulate the Aggregation of Amyloid-β and α-Synuclein and Suppress the Toxicity of Their Oligomers
por: Limbocker, Ryan, et al.
Publicado: (2021)

Identification of Novel 1,3,5-Triphenylbenzene Derivative Compounds as Inhibitors of Hen Lysozyme Amyloid Fibril Formation
por: Ramshini, Hassan, et al.
Publicado: (2019)

An in situ and in vitro investigation of cytoplasmic TDP-43 inclusions reveals the absence of a clear amyloid signature
por: Cascella, Roberta, et al.
Publicado: (2022)

Probing the Structure of Toxic Amyloid-β Oligomers with Electron Spin Resonance and Molecular Modeling
por: Banchelli, Martina, et al.
Publicado: (2021)

Chaperones as Suppressors of Protein Misfolded Oligomer Toxicity
por: Mannini, Benedetta, et al.
Publicado: (2017)

Interaction of microRNAs with sphingosine kinases, sphingosine-1 phosphate, and sphingosine-1 phosphate receptors in cancer
por: Xu, Guangmeng, et al.
Publicado: (2021)

TDP-43 Inclusion Bodies Formed in Bacteria Are Structurally Amorphous, Non-Amyloid and Inherently Toxic to Neuroblastoma Cells
por: Capitini, Claudia, et al.
Publicado: (2014)

Amyloid Beta Oligomers-Induced Ca(2+) Entry Pathways: Role of Neuronal Networks, NMDA Receptors and Amyloid Channel Formation
por: Caballero, Erica, et al.
Publicado: (2022)

S1P Signalling Axis Is Necessary for Adiponectin-Directed Regulation of Electrophysiological Properties and Oxidative Metabolism in C2C12 Myotubes
por: Bernacchioni, Caterina, et al.
Publicado: (2022)

A quantitative biology approach correlates neuronal toxicity with the largest inclusions of TDP-43
por: Cascella, Roberta, et al.
Publicado: (2022)

Adiponectin Modulates Smooth Muscle Cell Morpho-Functional Properties in Murine Gastric Fundus via Sphingosine Kinase 2 Activation
por: Garella, Rachele, et al.
Publicado: (2023)

The Role of Sphingolipids and Sphingosine-1-phosphate—Sphingosine-1-phosphate-receptor Signaling in Psoriasis
por: Masuda-Kuroki, Kana, et al.
Publicado: (2023)

Sphingosine kinases regulate ER contacts with late endocytic organelles and cholesterol trafficking
por: Palladino, Elisa N. D., et al.
Publicado: (2022)

Sphingosine 1-Phosphate and Atherosclerosis
por: Kurano, Makoto, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_o1tqoam6frfvplok3sekh41qad