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A fast GPU‐accelerated Monte Carlo engine for calculation of MLC‐collimated electron fields

BACKGROUND: Although intensity‐modulated radiation therapy and volumetric arc therapy have revolutionized photon external beam therapies, the technological advances associated with electron beam therapy have fallen behind. Modern linear accelerators contain technologies that would allow for more adv...

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Autores principales: Brost, Eric E., Wan Chan Tseung, H., Antolak, John A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087940/
https://www.ncbi.nlm.nih.gov/pubmed/35986907
http://dx.doi.org/10.1002/mp.15938
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author Brost, Eric E.
Wan Chan Tseung, H.
Antolak, John A.
author_facet Brost, Eric E.
Wan Chan Tseung, H.
Antolak, John A.
author_sort Brost, Eric E.
collection PubMed
description BACKGROUND: Although intensity‐modulated radiation therapy and volumetric arc therapy have revolutionized photon external beam therapies, the technological advances associated with electron beam therapy have fallen behind. Modern linear accelerators contain technologies that would allow for more advanced forms of electron treatments, such as beam collimation, using the conventional photon multi‐leaf collimator (MLC); however, no commercial solutions exist that calculate dose from such beam delivery modes. Additionally, for clinical adoption to occur, dose calculation times would need to be on par with that of modern dose calculation algorithms. PURPOSE: This work developed a graphics processing unit (GPU)‐accelerated Monte Carlo (MC) engine incorporating the Varian TrueBeam linac head geometry for a rapid calculation of electron beams collimated using the conventional photon MLC. METHODS: A compute unified device architecture framework was created for the following: (1) transport of electrons and photons through the linac head geometry, considering multiple scattering, Bremsstrahlung, Møller, Compton, and pair production interactions; (2) electron and photon propagation through the CT geometry, considering all interactions plus the photoelectric effect; and (3) secondary particle cascades through the linac head and within the CT geometry. The linac head collimating geometry was modeled according to the specifications provided by the vendor, who also provided phase‐space files. The MC was benchmarked against EGSnrc/DOSXYZnrc/GEANT by simulating individual interactions with simple geometries, pencil, and square beam dose calculations in various phantoms. MC‐calculated dose distributions for MLC and jaw‐collimated electron fields were compared to measurements in a water phantom and with radiochromic film. RESULTS: Pencil and square beam dose distributions are in good agreement with DOSXYZnrc. Angular and spatial distributions for multiple scattering and secondary particle production in thin slab geometries are in good agreement with EGSnrc and GEANT. Dose profiles for MLC and jaw‐collimated 6–20‐MeV electron beams showed an average absolute difference of 1.1 and 1.9 mm for the FWHM and 80%–20% penumbra from measured profiles. Percent depth doses showed differences of <5% for as compared to measurement. The computation time on an NVIDIA Tesla V100 card was 2.5 min to achieve a dose uncertainty of <1%, which is ∼300 times faster than published results in a similar geometry using a single‐CPU core. CONCLUSIONS: The GPU‐based MC can quickly calculate dose for electron fields collimated using the conventional photon MLC. The fast calculation times will allow for a rapid calculation of electron fields for mixed photon and electron particle therapy.
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spelling pubmed-100879402023-04-12 A fast GPU‐accelerated Monte Carlo engine for calculation of MLC‐collimated electron fields Brost, Eric E. Wan Chan Tseung, H. Antolak, John A. Med Phys COMPUTATIONAL AND EXPERIMENTAL DOSIMETRY BACKGROUND: Although intensity‐modulated radiation therapy and volumetric arc therapy have revolutionized photon external beam therapies, the technological advances associated with electron beam therapy have fallen behind. Modern linear accelerators contain technologies that would allow for more advanced forms of electron treatments, such as beam collimation, using the conventional photon multi‐leaf collimator (MLC); however, no commercial solutions exist that calculate dose from such beam delivery modes. Additionally, for clinical adoption to occur, dose calculation times would need to be on par with that of modern dose calculation algorithms. PURPOSE: This work developed a graphics processing unit (GPU)‐accelerated Monte Carlo (MC) engine incorporating the Varian TrueBeam linac head geometry for a rapid calculation of electron beams collimated using the conventional photon MLC. METHODS: A compute unified device architecture framework was created for the following: (1) transport of electrons and photons through the linac head geometry, considering multiple scattering, Bremsstrahlung, Møller, Compton, and pair production interactions; (2) electron and photon propagation through the CT geometry, considering all interactions plus the photoelectric effect; and (3) secondary particle cascades through the linac head and within the CT geometry. The linac head collimating geometry was modeled according to the specifications provided by the vendor, who also provided phase‐space files. The MC was benchmarked against EGSnrc/DOSXYZnrc/GEANT by simulating individual interactions with simple geometries, pencil, and square beam dose calculations in various phantoms. MC‐calculated dose distributions for MLC and jaw‐collimated electron fields were compared to measurements in a water phantom and with radiochromic film. RESULTS: Pencil and square beam dose distributions are in good agreement with DOSXYZnrc. Angular and spatial distributions for multiple scattering and secondary particle production in thin slab geometries are in good agreement with EGSnrc and GEANT. Dose profiles for MLC and jaw‐collimated 6–20‐MeV electron beams showed an average absolute difference of 1.1 and 1.9 mm for the FWHM and 80%–20% penumbra from measured profiles. Percent depth doses showed differences of <5% for as compared to measurement. The computation time on an NVIDIA Tesla V100 card was 2.5 min to achieve a dose uncertainty of <1%, which is ∼300 times faster than published results in a similar geometry using a single‐CPU core. CONCLUSIONS: The GPU‐based MC can quickly calculate dose for electron fields collimated using the conventional photon MLC. The fast calculation times will allow for a rapid calculation of electron fields for mixed photon and electron particle therapy. John Wiley and Sons Inc. 2022-08-31 2023-01 /pmc/articles/PMC10087940/ /pubmed/35986907 http://dx.doi.org/10.1002/mp.15938 Text en © 2022 The Authors. Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle COMPUTATIONAL AND EXPERIMENTAL DOSIMETRY
Brost, Eric E.
Wan Chan Tseung, H.
Antolak, John A.
A fast GPU‐accelerated Monte Carlo engine for calculation of MLC‐collimated electron fields
title A fast GPU‐accelerated Monte Carlo engine for calculation of MLC‐collimated electron fields
title_full A fast GPU‐accelerated Monte Carlo engine for calculation of MLC‐collimated electron fields
title_fullStr A fast GPU‐accelerated Monte Carlo engine for calculation of MLC‐collimated electron fields
title_full_unstemmed A fast GPU‐accelerated Monte Carlo engine for calculation of MLC‐collimated electron fields
title_short A fast GPU‐accelerated Monte Carlo engine for calculation of MLC‐collimated electron fields
title_sort fast gpu‐accelerated monte carlo engine for calculation of mlc‐collimated electron fields
topic COMPUTATIONAL AND EXPERIMENTAL DOSIMETRY
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10087940/
https://www.ncbi.nlm.nih.gov/pubmed/35986907
http://dx.doi.org/10.1002/mp.15938
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