A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes

[Image: see text] Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide...

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Autores principales: De Rosa, Lucia, Hawala, Ivan, Di Stasi, Rossella, Stefania, Rachele, Capozza, Martina, Nava, Donatella, D’Andrea, Luca Domenico
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088022/
https://www.ncbi.nlm.nih.gov/pubmed/36988421
http://dx.doi.org/10.1021/acs.joc.3c00014
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author De Rosa, Lucia
Hawala, Ivan
Di Stasi, Rossella
Stefania, Rachele
Capozza, Martina
Nava, Donatella
D’Andrea, Luca Domenico
author_facet De Rosa, Lucia
Hawala, Ivan
Di Stasi, Rossella
Stefania, Rachele
Capozza, Martina
Nava, Donatella
D’Andrea, Luca Domenico
author_sort De Rosa, Lucia
collection PubMed
description [Image: see text] Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes.
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spelling pubmed-100880222023-04-12 A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes De Rosa, Lucia Hawala, Ivan Di Stasi, Rossella Stefania, Rachele Capozza, Martina Nava, Donatella D’Andrea, Luca Domenico J Org Chem [Image: see text] Multimodality probes appear of great interest for innovative imaging applications in disease diagnosis. Herein, we present a chemical strategy enabling site-specific double-modification and cyclization of a peptide probe exploiting native chemical ligation (NCL) and thiol-maleimide addition. The synthetic strategy is straightforward and of general applicability for the development of double-labeled peptide multimodality probes. American Chemical Society 2023-03-29 /pmc/articles/PMC10088022/ /pubmed/36988421 http://dx.doi.org/10.1021/acs.joc.3c00014 Text en © 2023 The Authors. Published by American Chemical Society https://creativecommons.org/licenses/by/4.0/Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/).
spellingShingle De Rosa, Lucia
Hawala, Ivan
Di Stasi, Rossella
Stefania, Rachele
Capozza, Martina
Nava, Donatella
D’Andrea, Luca Domenico
A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes
title A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes
title_full A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes
title_fullStr A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes
title_full_unstemmed A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes
title_short A Chemical Strategy for the Preparation of Multimodified Peptide Imaging Probes
title_sort chemical strategy for the preparation of multimodified peptide imaging probes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088022/
https://www.ncbi.nlm.nih.gov/pubmed/36988421
http://dx.doi.org/10.1021/acs.joc.3c00014
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