Discovery and Rational Mutagenesis of Methionine Sulfoxide Reductase Biocatalysts To Expand the Substrate Scope of the Kinetic Resolution of Chiral Sulfoxides

[Image: see text] Methionine sulfoxide reductase A (MsrA) enzymes have recently found applications as nonoxidative biocatalysts in the enantioselective kinetic resolution of racemic sulfoxides. This work describes the identification of selective and robust MsrA biocatalysts able to catalyze the enan...

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Detalles Bibliográficos
Autores principales: Anselmi, Silvia, Carvalho, Alexandra T. P., Serrano-Sanchez, Angela, Ortega-Roldan, Jose L., Caswell, Jill, Omar, Iman, Perez-Ortiz, Gustavo, Barry, Sarah M., Moody, Thomas S., Castagnolo, Daniele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088026/
https://www.ncbi.nlm.nih.gov/pubmed/37066047
http://dx.doi.org/10.1021/acscatal.3c00372

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