Identification of shared fatty acid metabolism related signatures in dilated cardiomyopathy and myocardial infarction

AIM: It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction. MATERIALS & METHODS: Four gene enrichment analyses defined DE-FRGs’ biological functions and pathways. Three s...

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Detalles Bibliográficos
Autores principales: Huang, Baoyi, Lin, Hanying, Zhang, Qingfang, Luo, Yujun, Zhou, Biyao, Zhuo, Zewei, Sha, Weihong, Wei, Jiahui, Luo, Lihua, Zhang, Huajuan, Chen, Kequan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Science Ltd 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088053/
https://www.ncbi.nlm.nih.gov/pubmed/37056578
http://dx.doi.org/10.2144/fsoa-2023-0008
Descripción
Sumario:AIM: It is to be elucidated the risk-predictive role of differentially expressed fatty acid metabolism related genes (DE-FRGs) in dilated cardiomyopathy (DCM) and myocardial infarction. MATERIALS & METHODS: Four gene enrichment analyses defined DE-FRGs’ biological functions and pathways. Three strategies were applied to identify risk biomarkers and construct a nomogram. The 4-DE-FRG correlation with immune cell infiltration, drugs, and ceRNA was explored. RESULTS: DE-FRGs were enriched in lipid metabolism. A risk nomogram was established by ACSL1, ALDH2, CYP27A1 and PPARA, demonstrating a good ability for DCM and myocardial infarction prediction. PPARA was positively correlated with adaptive immunocytes. Thirty-five drugs are candidate therapeutic targets. CONCLUSION: A nomogram and new biological targets for early diagnosis and treatment of DCM and myocardial infarction were provided.

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