Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance

Here we present an iridium catalysed C2-selective methylation of indoles using methyltrifluoroborate as a source of methyl group. The iridium catalyst selectively discriminates the indole C2 and C4 C–H bonds by coordination with a pivaloyl directing group.

Detalles Bibliográficos
Autores principales: Kathiravan, Subban, Zhang, Tianshu, Nicholls, Ian A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088075/
https://www.ncbi.nlm.nih.gov/pubmed/37057266
http://dx.doi.org/10.1039/d3ra02031b
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author Kathiravan, Subban
Zhang, Tianshu
Nicholls, Ian A.
author_facet Kathiravan, Subban
Zhang, Tianshu
Nicholls, Ian A.
author_sort Kathiravan, Subban
collection PubMed
description Here we present an iridium catalysed C2-selective methylation of indoles using methyltrifluoroborate as a source of methyl group. The iridium catalyst selectively discriminates the indole C2 and C4 C–H bonds by coordination with a pivaloyl directing group.
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spelling pubmed-100880752023-04-12 Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance Kathiravan, Subban Zhang, Tianshu Nicholls, Ian A. RSC Adv Chemistry Here we present an iridium catalysed C2-selective methylation of indoles using methyltrifluoroborate as a source of methyl group. The iridium catalyst selectively discriminates the indole C2 and C4 C–H bonds by coordination with a pivaloyl directing group. The Royal Society of Chemistry 2023-04-11 /pmc/articles/PMC10088075/ /pubmed/37057266 http://dx.doi.org/10.1039/d3ra02031b Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Kathiravan, Subban
Zhang, Tianshu
Nicholls, Ian A.
Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
title Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
title_full Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
title_fullStr Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
title_full_unstemmed Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
title_short Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
title_sort iridium catalysed c2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088075/
https://www.ncbi.nlm.nih.gov/pubmed/37057266
http://dx.doi.org/10.1039/d3ra02031b
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AT nichollsiana iridiumcatalysedc2siteselectivemethylationofindolesusingapivaloyldirectinggroupthroughweakchelationassistance

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