Cargando…
Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance
Here we present an iridium catalysed C2-selective methylation of indoles using methyltrifluoroborate as a source of methyl group. The iridium catalyst selectively discriminates the indole C2 and C4 C–H bonds by coordination with a pivaloyl directing group.
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Royal Society of Chemistry
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088075/ https://www.ncbi.nlm.nih.gov/pubmed/37057266 http://dx.doi.org/10.1039/d3ra02031b |