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Tiered approach to evaluate the CYP3A victim and perpetrator drug–drug interaction potential for vonoprazan using PBPK modeling and clinical data to inform labeling

Vonoprazan is metabolized extensively through CYP3A and is an in vitro time‐dependent inhibitor of CYP3A. A tiered approach was applied to understand the CYP3A victim and perpetrator drug–drug interaction (DDI) potential for vonoprazan. Mechanistic static modeling suggested vonoprazan is a potential...

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Detalles Bibliográficos
Autores principales:	Mulford, Darcy J., Ramsden, Diane, Zhang, Liming, Michon, Ingrid, Leifke, Eckhard, Smith, Neila, Jones, Hannah M., Scarpignato, Carmelo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088082/ https://www.ncbi.nlm.nih.gov/pubmed/36896795 http://dx.doi.org/10.1002/psp4.12939

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