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Deriving mechanism‐based pharmacodynamic models by reducing quantitative systems pharmacology models: An application to warfarin

Quantitative systems pharmacology (QSP) models integrate comprehensive qualitative and quantitative knowledge about pharmacologically relevant processes. We previously proposed a first approach to leverage the knowledge in QSP models to derive simpler, mechanism‐based pharmacodynamic (PD) models. Th...

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Detalles Bibliográficos
Autores principales:	Falkenhagen, Undine, Knöchel, Jane, Kloft, Charlotte, Huisinga, Wilhelm
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088086/ https://www.ncbi.nlm.nih.gov/pubmed/36866520 http://dx.doi.org/10.1002/psp4.12903

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