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Synergistic FRET assays for drug discovery targeting RyR2 channels

A key therapeutic target for heart failure and arrhythmia is the deleterious leak through sarcoplasmic reticulum (SR) ryanodine receptor 2 (RyR2) calcium release channels. We have previously developed methods to detect the pathologically leaky state of RyR2 in adult cardiomyocytes by monitoring RyR2...

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Detalles Bibliográficos
Autores principales:	Rebbeck, RobynT., Ginsburg, Kenneth S., Ko, Christopher Y., Fasoli, Anna, Rusch, Katherine, Cai, George F., Dong, Xiaoqiong, Thomas, David D., Bers, Donald M., Cornea, Razvan L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088286/ https://www.ncbi.nlm.nih.gov/pubmed/35405106 http://dx.doi.org/10.1016/j.yjmcc.2022.04.002

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