Co-crystal of nadifloxacin with oxalic acid

The 2:1 co-crystal of nadifloxacin [systematic name: 9-fluoro-8-(4-hy­droxy­piperidin-1-yl)-5-methyl-1-oxo-6,7-di­hydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carb­oxy­lic acid] with oxalic acid, C(19)H(21)FN(2)O(4)·0.5C(2)H(2)O(4), was prepared by slow evaporation from a chloro­form:acetone solvent syst...

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Autores principales: Karthammaiah, Geethanjali N., Rao Amaraneni, Sreenivasa, Solomon, Anand K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2023
Materias:
Research Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088309/
https://www.ncbi.nlm.nih.gov/pubmed/37057007
http://dx.doi.org/10.1107/S2056989023002244
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author Karthammaiah, Geethanjali N.
Rao Amaraneni, Sreenivasa
Solomon, Anand K.
author_facet Karthammaiah, Geethanjali N.
Rao Amaraneni, Sreenivasa
Solomon, Anand K.
author_sort Karthammaiah, Geethanjali N.
collection PubMed
description The 2:1 co-crystal of nadifloxacin [systematic name: 9-fluoro-8-(4-hy­droxy­piperidin-1-yl)-5-methyl-1-oxo-6,7-di­hydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carb­oxy­lic acid] with oxalic acid, C(19)H(21)FN(2)O(4)·0.5C(2)H(2)O(4), was prepared by slow evaporation from a chloro­form:acetone solvent system. Nadifloxacin belongs to the group of anti­bacterial drugs. The co-crystal is stabilized through an intra­molecular O—H⋯O bond and inter­molecular hydrogen bonds. It was studied by FT–IR spectroscopy, differential scanning calorimetry and X-ray diffraction. Hirshfeld surface analysis indicated that the major contribution to the packing is from O⋯H/H⋯O inter­actions.
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spelling pubmed-100883092023-04-12 Co-crystal of nadifloxacin with oxalic acid Karthammaiah, Geethanjali N. Rao Amaraneni, Sreenivasa Solomon, Anand K. Acta Crystallogr E Crystallogr Commun Research Communications The 2:1 co-crystal of nadifloxacin [systematic name: 9-fluoro-8-(4-hy­droxy­piperidin-1-yl)-5-methyl-1-oxo-6,7-di­hydro-1H,5H-pyrido[3,2,1-ij]quinoline-2-carb­oxy­lic acid] with oxalic acid, C(19)H(21)FN(2)O(4)·0.5C(2)H(2)O(4), was prepared by slow evaporation from a chloro­form:acetone solvent system. Nadifloxacin belongs to the group of anti­bacterial drugs. The co-crystal is stabilized through an intra­molecular O—H⋯O bond and inter­molecular hydrogen bonds. It was studied by FT–IR spectroscopy, differential scanning calorimetry and X-ray diffraction. Hirshfeld surface analysis indicated that the major contribution to the packing is from O⋯H/H⋯O inter­actions. International Union of Crystallography 2023-03-10 /pmc/articles/PMC10088309/ /pubmed/37057007 http://dx.doi.org/10.1107/S2056989023002244 Text en © Karthammaiah et al. 2023 https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC-BY) Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original authors and source are cited.
spellingShingle Research Communications
Karthammaiah, Geethanjali N.
Rao Amaraneni, Sreenivasa
Solomon, Anand K.
Co-crystal of nadifloxacin with oxalic acid
title Co-crystal of nadifloxacin with oxalic acid
title_full Co-crystal of nadifloxacin with oxalic acid
title_fullStr Co-crystal of nadifloxacin with oxalic acid
title_full_unstemmed Co-crystal of nadifloxacin with oxalic acid
title_short Co-crystal of nadifloxacin with oxalic acid
title_sort co-crystal of nadifloxacin with oxalic acid
topic Research Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088309/
https://www.ncbi.nlm.nih.gov/pubmed/37057007
http://dx.doi.org/10.1107/S2056989023002244
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