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Fatty acid metabolism: A new therapeutic target for cervical cancer

Cervical cancer (CC) is one of the most common malignancies in women. Cancer cells can use metabolic reprogramming to produce macromolecules and ATP needed to sustain cell growth, division and survival. Recent evidence suggests that fatty acid metabolism and its related lipid metabolic pathways are...

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Detalles Bibliográficos
Autores principales: Ping, Pengbin, Li, Juan, Lei, Hongbin, Xu, Xiaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088509/
https://www.ncbi.nlm.nih.gov/pubmed/37056351
http://dx.doi.org/10.3389/fonc.2023.1111778
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author Ping, Pengbin
Li, Juan
Lei, Hongbin
Xu, Xiaoying
author_facet Ping, Pengbin
Li, Juan
Lei, Hongbin
Xu, Xiaoying
author_sort Ping, Pengbin
collection PubMed
description Cervical cancer (CC) is one of the most common malignancies in women. Cancer cells can use metabolic reprogramming to produce macromolecules and ATP needed to sustain cell growth, division and survival. Recent evidence suggests that fatty acid metabolism and its related lipid metabolic pathways are closely related to the malignant progression of CC. In particular, it involves the synthesis, uptake, activation, oxidation, and transport of fatty acids. Similarly, more and more attention has been paid to the effects of intracellular lipolysis, transcriptional regulatory factors, other lipid metabolic pathways and diet on CC. This study reviews the latest evidence of the link between fatty acid metabolism and CC; it not only reveals its core mechanism but also discusses promising targeted drugs for fatty acid metabolism. This study on the complex relationship between carcinogenic signals and fatty acid metabolism suggests that fatty acid metabolism will become a new therapeutic target in CC.
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spelling pubmed-100885092023-04-12 Fatty acid metabolism: A new therapeutic target for cervical cancer Ping, Pengbin Li, Juan Lei, Hongbin Xu, Xiaoying Front Oncol Oncology Cervical cancer (CC) is one of the most common malignancies in women. Cancer cells can use metabolic reprogramming to produce macromolecules and ATP needed to sustain cell growth, division and survival. Recent evidence suggests that fatty acid metabolism and its related lipid metabolic pathways are closely related to the malignant progression of CC. In particular, it involves the synthesis, uptake, activation, oxidation, and transport of fatty acids. Similarly, more and more attention has been paid to the effects of intracellular lipolysis, transcriptional regulatory factors, other lipid metabolic pathways and diet on CC. This study reviews the latest evidence of the link between fatty acid metabolism and CC; it not only reveals its core mechanism but also discusses promising targeted drugs for fatty acid metabolism. This study on the complex relationship between carcinogenic signals and fatty acid metabolism suggests that fatty acid metabolism will become a new therapeutic target in CC. Frontiers Media S.A. 2023-03-28 /pmc/articles/PMC10088509/ /pubmed/37056351 http://dx.doi.org/10.3389/fonc.2023.1111778 Text en Copyright © 2023 Ping, Li, Lei and Xu https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ping, Pengbin
Li, Juan
Lei, Hongbin
Xu, Xiaoying
Fatty acid metabolism: A new therapeutic target for cervical cancer
title Fatty acid metabolism: A new therapeutic target for cervical cancer
title_full Fatty acid metabolism: A new therapeutic target for cervical cancer
title_fullStr Fatty acid metabolism: A new therapeutic target for cervical cancer
title_full_unstemmed Fatty acid metabolism: A new therapeutic target for cervical cancer
title_short Fatty acid metabolism: A new therapeutic target for cervical cancer
title_sort fatty acid metabolism: a new therapeutic target for cervical cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088509/
https://www.ncbi.nlm.nih.gov/pubmed/37056351
http://dx.doi.org/10.3389/fonc.2023.1111778
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AT xuxiaoying fattyacidmetabolismanewtherapeutictargetforcervicalcancer