Cargando…

A mechanism study of DUSP1 in inhibiting malignant progression of endometrial carcinoma by regulating ERK/AP-1 axis and dephosphorylation of EPHA2

Background: Endometrial carcinoma is one of the most common female malignancies worldwide. Based on our preliminary investigation, DUSP1 was identified as a potential biomarker for endometrial carcinoma prognosis, but its function and mechanism remained unclear. Methods: In this study, genes highly...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lei, Shu, He, Xiangjun, Yang, Xiao, Gu, Xuan, He, Yijiao, Wang, Jianliu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088542/ https://www.ncbi.nlm.nih.gov/pubmed/37057290 http://dx.doi.org/10.7150/jca.81069

Ejemplares similares

Dusp6 Inhibits Epithelial-mesenchymal Transition in Endometrial Adenocarcinoma Via ERK Signaling Pathway
por: Fan, Ming-Jun, et al.
Publicado: (2019)

DUSP5 functions as a feedback regulator of TNFα-induced ERK1/2 dephosphorylation and inflammatory gene expression in adipocytes
por: Habibian, Justine S., et al.
Publicado: (2017)

Connexin 32 dysfunction promotes ethanol-related hepatocarcinogenesis via activation of Dusp1-Erk axis
por: Kato, Hiroyuki, et al.
Publicado: (2015)

DUSP6 SUMOylation protects cells from oxidative damage via direct regulation of Drp1 dephosphorylation
por: Ma, Ruining, et al.
Publicado: (2020)

ATX-LPA axis facilitates estrogen-induced endometrial cancer cell proliferation via MAPK/ERK signaling pathway
por: Zhang, Guo, et al.
Publicado: (2018)

PTEN regulates invasiveness in pancreatic neuroendocrine tumors through DUSP19-mediated VEGFR3 dephosphorylation
por: Chang, Tsung-Ming, et al.
Publicado: (2022)

Deregulation of cell adhesion molecules is associated with progression and poor outcomes in endometrial cancer: Analysis of The Cancer Genome Atlas data
por: He, Xiangjun, et al.
Publicado: (2020)

CIC Is a Mediator of the ERK1/2-DUSP6 Negative Feedback Loop
por: Ren, Yibo, et al.
Publicado: (2020)

The MAPK/ERK Pathway and the Role of DUSP1 in JCPyV Infection of Primary Astrocytes
por: Wilczek, Michael P., et al.
Publicado: (2021)

Maintenance Therapy Can Improve the Oncologic Prognosis and Obstetrical Outcome of Patients With Atypical Endometrial Hyperplasia and Endometrial Cancer After Fertility-Preserving Treatment: A Multicenter Retrospective Study
por: He, Yijiao, et al.
Publicado: (2021)

Regorafenib inhibits EphA2 phosphorylation and leads to liver damage via the ERK/MDM2/p53 axis
por: Yan, Hao, et al.
Publicado: (2023)

Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2
por: Perander, Maria, et al.
Publicado: (2017)

Combination of EphA2- and Wee1-Targeted Therapies in Endometrial Cancer
por: Dasari, Santosh K., et al.
Publicado: (2023)

Use of clinicopathological factors to predict prognosis of fertility-sparing treatment for endometrial endometrioid carcinoma and atypical hyperplasia
por: Zhang, Xiaobo, et al.
Publicado: (2022)

ERK Dephosphorylation through MKP1 Deacetylation by SIRT1 Attenuates RAS-Driven Tumorigenesis
por: Kwon, Ok-Seon, et al.
Publicado: (2020)

Nucleophosmin Protein Dephosphorylation by DUSP3 Is a Fine-Tuning Regulator of p53 Signaling to Maintain Genomic Stability
por: Russo, Lilian C., et al.
Publicado: (2021)

Glucocorticoid receptor inhibits Müller glial galectin‐1 expression via DUSP1‐dependent and ‐independent deactivation of AP‐1 signalling
por: Hirose, Ikuyo, et al.
Publicado: (2019)

Role of steroid receptor-associated and regulated protein in tumor progression and progesterone receptor signaling in endometrial cancer
por: Liu, Jie, et al.
Publicado: (2023)

NKX2-1 controls lung cancer progression by inducing DUSP6 to dampen ERK activity
por: Ingram, Kelley, et al.
Publicado: (2021)

DOCK1 insufficiency disrupts trophoblast function and pregnancy outcomes via DUSP4-ERK pathway
por: Xu, Yichi, et al.
Publicado: (2023)

The SKA3-DUSP2 Axis Promotes Gastric Cancer Tumorigenesis and Epithelial-Mesenchymal Transition by Activating the MAPK/ERK Pathway
por: Zhang, Chao, et al.
Publicado: (2022)

A positive feedback loop of ARF6 activates ERK1/2 signaling pathway via DUSP6 silencing to promote pancreatic cancer progression : ARF6 regulates ERK1/2 pathway by inhibiting DUSP6
por: Xiao, Bingkai, et al.
Publicado: (2022)

Reactive oxygen species mediate heat stress-induced apoptosis via ERK dephosphorylation and Bcl-2 ubiquitination in human umbilical vein endothelial cells
por: Li, Li, et al.
Publicado: (2016)

ADAP1 promotes latent HIV-1 reactivation by selectively tuning KRAS–ERK–AP-1 T cell signaling-transcriptional axis
por: Ramirez, Nora-Guadalupe P., et al.
Publicado: (2022)

Resilience to audiogenic seizures is associated with p-ERK1/2 dephosphorylation in the subiculum of Fmr1 knockout mice
por: Curia, Giulia, et al.
Publicado: (2013)

DUSP5 and DUSP6, two ERK specific phosphatases, are markers of a higher MAPK signaling activation in BRAF mutated thyroid cancers
por: Buffet, Camille, et al.
Publicado: (2017)

MicroRNA-641 Inhibits Endometrial Cancer Progression via Targeting AP1G1
por: Dong, Yanfen, et al.
Publicado: (2022)

Activation of ERK1/2 Causes Pazopanib Resistance via Downregulation of DUSP6 in Synovial Sarcoma Cells
por: Yokoyama, Nobuhiko, et al.
Publicado: (2017)

CCR7 mediates the TNF-α-induced lymphatic metastasis of gallbladder cancer through the “ERK1/2 - AP-1” and “JNK - AP-1” pathways
por: Hong, HaiJie, et al.
Publicado: (2016)

Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma
por: Su, Renyi, et al.
Publicado: (2022)

Chloroquine and Rapamycin Augment Interleukin-37 Expression via the LC3, ERK, and AP-1 Axis in the Presence of Lipopolysaccharides
por: Shi, Xiaoyi, et al.
Publicado: (2020)

EphA3 targeted by miR-3666 contributes to melanoma malignancy via activating ERK1/2 and p38 MAPK pathways
por: Ming, Di, et al.
Publicado: (2022)

Predicting prognosis of endometrioid endometrial adenocarcinoma on the basis of gene expression and clinical features using Random Forest
por: Yin, Fufen, et al.
Publicado: (2019)

Y772 phosphorylation of EphA2 is responsible for EphA2-dependent NPC nasopharyngeal carcinoma growth by Shp2/Erk-1/2 signaling pathway
por: Xiang, Yi-Ping, et al.
Publicado: (2020)

Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling
por: Hamnett, Ryan, et al.
Publicado: (2019)

Mutant PIK3CA controls DUSP1-dependent ERK 1/2 activity to confer response to AKT target therapy
por: Sathe, A, et al.
Publicado: (2014)

DNTTIP1 promotes nasopharyngeal carcinoma metastasis via recruiting HDAC1 to DUSP2 promoter and activating ERK signaling pathway
por: Ding, Shirong, et al.
Publicado: (2022)

The cytotoxic action of BCI is not dependent on its stated DUSP1 or DUSP6 targets in neuroblastoma cells
por: Thompson, Elliott M., et al.
Publicado: (2022)

CDK5 functions as a tumor promoter in human colorectal cancer via modulating the ERK5–AP-1 axis
por: Zhuang, Kangmin, et al.
Publicado: (2016)

The Ninj1/Dusp1 Axis Contributes to Liver Ischemia Reperfusion Injury by Regulating Macrophage Activation and Neutrophil Infiltration
por: Hu, Yuanchang, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_b8n4altrf47efbn43neqmd2g2r