Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome

The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by intratracheal administration of 0.5 mg/kg LPS or 0.04 ml acidin-pepsin (pH 1.2). Inhalation of the oxygen-xenon mixture inhibited the development and reduced th...

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Autores principales: Fedorova, E. P., Filonova, M. V., Churin, A. A., Naumov, S. A., Nikiforov, P. E., Sandrikina, L. A., Evtushenko, D. N., Udut, E. V., Popov, O. S., Naumov, S. S., Fomina, T. I., Udut, V. V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088570/
https://www.ncbi.nlm.nih.gov/pubmed/37040041
http://dx.doi.org/10.1007/s10517-023-05755-9
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author Fedorova, E. P.
Filonova, M. V.
Churin, A. A.
Naumov, S. A.
Nikiforov, P. E.
Sandrikina, L. A.
Evtushenko, D. N.
Udut, E. V.
Popov, O. S.
Naumov, S. S.
Fomina, T. I.
Udut, V. V.
author_facet Fedorova, E. P.
Filonova, M. V.
Churin, A. A.
Naumov, S. A.
Nikiforov, P. E.
Sandrikina, L. A.
Evtushenko, D. N.
Udut, E. V.
Popov, O. S.
Naumov, S. S.
Fomina, T. I.
Udut, V. V.
author_sort Fedorova, E. P.
collection PubMed
description The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by intratracheal administration of 0.5 mg/kg LPS or 0.04 ml acidin-pepsin (pH 1.2). Inhalation of the oxygen-xenon mixture inhibited the development and reduced the intensity of the inflammatory process in the lung tissue, which was assessed by the dynamics of lung weight and body weight of animals: the therapeutic exposure decreased both parameters. It was found that the thrombogenic stimulus, pathognomonic for the development of acute respiratory distress syndrome, decreased under the effect of oxygen-xenon inhalations, while the level of natural anticoagulant antithrombin III increased.
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spelling pubmed-100885702023-04-12 Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome Fedorova, E. P. Filonova, M. V. Churin, A. A. Naumov, S. A. Nikiforov, P. E. Sandrikina, L. A. Evtushenko, D. N. Udut, E. V. Popov, O. S. Naumov, S. S. Fomina, T. I. Udut, V. V. Bull Exp Biol Med Article The effects of inhalations of an oxygen-xenon (70%/30%) mixture were studied in two models of acute respiratory distress syndrome caused by intratracheal administration of 0.5 mg/kg LPS or 0.04 ml acidin-pepsin (pH 1.2). Inhalation of the oxygen-xenon mixture inhibited the development and reduced the intensity of the inflammatory process in the lung tissue, which was assessed by the dynamics of lung weight and body weight of animals: the therapeutic exposure decreased both parameters. It was found that the thrombogenic stimulus, pathognomonic for the development of acute respiratory distress syndrome, decreased under the effect of oxygen-xenon inhalations, while the level of natural anticoagulant antithrombin III increased. Springer US 2023-04-11 2023 /pmc/articles/PMC10088570/ /pubmed/37040041 http://dx.doi.org/10.1007/s10517-023-05755-9 Text en © Springer Science+Business Media, LLC, part of Springer Nature 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Article
Fedorova, E. P.
Filonova, M. V.
Churin, A. A.
Naumov, S. A.
Nikiforov, P. E.
Sandrikina, L. A.
Evtushenko, D. N.
Udut, E. V.
Popov, O. S.
Naumov, S. S.
Fomina, T. I.
Udut, V. V.
Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
title Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
title_full Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
title_fullStr Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
title_full_unstemmed Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
title_short Xenon-Induced Effects in Relieving Experimental Acute Respiratory Distress Syndrome
title_sort xenon-induced effects in relieving experimental acute respiratory distress syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088570/
https://www.ncbi.nlm.nih.gov/pubmed/37040041
http://dx.doi.org/10.1007/s10517-023-05755-9
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