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Exploring relationships between autistic traits and body temperature, circadian rhythms, and age

The number of clinical diagnoses of autism spectrum disorder (ASD) is increasing annually. Interestingly, the human body temperature has also been reported to gradually decrease over the decades. An imbalance in the activation of the excitatory and inhibitory neurons is assumed to be involved in the...

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Autores principales: Hidaka, Souta, Gotoh, Mizuho, Yamamoto, Shinya, Wada, Makoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088634/
https://www.ncbi.nlm.nih.gov/pubmed/37041298
http://dx.doi.org/10.1038/s41598-023-32449-z
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author Hidaka, Souta
Gotoh, Mizuho
Yamamoto, Shinya
Wada, Makoto
author_facet Hidaka, Souta
Gotoh, Mizuho
Yamamoto, Shinya
Wada, Makoto
author_sort Hidaka, Souta
collection PubMed
description The number of clinical diagnoses of autism spectrum disorder (ASD) is increasing annually. Interestingly, the human body temperature has also been reported to gradually decrease over the decades. An imbalance in the activation of the excitatory and inhibitory neurons is assumed to be involved in the pathogenesis of ASD. Neurophysiological evidence showed that brain activity decreases as cortical temperature increases, suggesting that an increase in brain temperature enhances the inhibitory neural mechanisms. Behavioral characteristics specific to clinical ASD were observed to be moderated when people with the diagnoses had a fever. To explore the possible relationship between ASD and body temperature in the general population, we conducted a survey study using a large population-based sample (N ~ 2000, in the age groups 20s to 70s). Through two surveys, multiple regression analyses did not show significant relationships between axillary temperatures and autistic traits measured by questionnaires (Autism Spectrum (AQ) and Empathy/Systemizing Quotients), controlling for covariates of age and self-reported circadian rhythms. Conversely, we consistently observed a negative relationship between AQ and age. People with higher AQ scores tended to have stronger eveningness. Our findings contribute to the understanding of age-related malleability and the irregularity of circadian rhythms related to autistic traits.
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spelling pubmed-100886342023-04-12 Exploring relationships between autistic traits and body temperature, circadian rhythms, and age Hidaka, Souta Gotoh, Mizuho Yamamoto, Shinya Wada, Makoto Sci Rep Article The number of clinical diagnoses of autism spectrum disorder (ASD) is increasing annually. Interestingly, the human body temperature has also been reported to gradually decrease over the decades. An imbalance in the activation of the excitatory and inhibitory neurons is assumed to be involved in the pathogenesis of ASD. Neurophysiological evidence showed that brain activity decreases as cortical temperature increases, suggesting that an increase in brain temperature enhances the inhibitory neural mechanisms. Behavioral characteristics specific to clinical ASD were observed to be moderated when people with the diagnoses had a fever. To explore the possible relationship between ASD and body temperature in the general population, we conducted a survey study using a large population-based sample (N ~ 2000, in the age groups 20s to 70s). Through two surveys, multiple regression analyses did not show significant relationships between axillary temperatures and autistic traits measured by questionnaires (Autism Spectrum (AQ) and Empathy/Systemizing Quotients), controlling for covariates of age and self-reported circadian rhythms. Conversely, we consistently observed a negative relationship between AQ and age. People with higher AQ scores tended to have stronger eveningness. Our findings contribute to the understanding of age-related malleability and the irregularity of circadian rhythms related to autistic traits. Nature Publishing Group UK 2023-04-11 /pmc/articles/PMC10088634/ /pubmed/37041298 http://dx.doi.org/10.1038/s41598-023-32449-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Hidaka, Souta
Gotoh, Mizuho
Yamamoto, Shinya
Wada, Makoto
Exploring relationships between autistic traits and body temperature, circadian rhythms, and age
title Exploring relationships between autistic traits and body temperature, circadian rhythms, and age
title_full Exploring relationships between autistic traits and body temperature, circadian rhythms, and age
title_fullStr Exploring relationships between autistic traits and body temperature, circadian rhythms, and age
title_full_unstemmed Exploring relationships between autistic traits and body temperature, circadian rhythms, and age
title_short Exploring relationships between autistic traits and body temperature, circadian rhythms, and age
title_sort exploring relationships between autistic traits and body temperature, circadian rhythms, and age
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088634/
https://www.ncbi.nlm.nih.gov/pubmed/37041298
http://dx.doi.org/10.1038/s41598-023-32449-z
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