Ewing sarcoma treatment: a gene therapy approach

Ewing sarcoma (ES) is an aggressive malignant tumor, characterized by non-random chromosomal translocations that produce fusion genes. Fusion genes and fusion protein products are promising targets for gene therapy. Therapeutic approaches and strategies vary based on target molecules (nucleotides, p...

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Autores principales: Tsibulnikov, Sergey, Fayzullina, Daria, Karlina, Irina, Schroeder, Brett A., Karpova, Olga, Timashev, Peter, Ulasov, Ilya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088695/
https://www.ncbi.nlm.nih.gov/pubmed/37037906
http://dx.doi.org/10.1038/s41417-023-00615-0
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author Tsibulnikov, Sergey
Fayzullina, Daria
Karlina, Irina
Schroeder, Brett A.
Karpova, Olga
Timashev, Peter
Ulasov, Ilya
author_facet Tsibulnikov, Sergey
Fayzullina, Daria
Karlina, Irina
Schroeder, Brett A.
Karpova, Olga
Timashev, Peter
Ulasov, Ilya
author_sort Tsibulnikov, Sergey
collection PubMed
description Ewing sarcoma (ES) is an aggressive malignant tumor, characterized by non-random chromosomal translocations that produce fusion genes. Fusion genes and fusion protein products are promising targets for gene therapy. Therapeutic approaches and strategies vary based on target molecules (nucleotides, proteins) of interest. We present an extensive literature review of active molecules for gene therapy and methods of gene therapy delivery, both of which are necessary for successful treatment.
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spelling pubmed-100886952023-04-12 Ewing sarcoma treatment: a gene therapy approach Tsibulnikov, Sergey Fayzullina, Daria Karlina, Irina Schroeder, Brett A. Karpova, Olga Timashev, Peter Ulasov, Ilya Cancer Gene Ther Review Article Ewing sarcoma (ES) is an aggressive malignant tumor, characterized by non-random chromosomal translocations that produce fusion genes. Fusion genes and fusion protein products are promising targets for gene therapy. Therapeutic approaches and strategies vary based on target molecules (nucleotides, proteins) of interest. We present an extensive literature review of active molecules for gene therapy and methods of gene therapy delivery, both of which are necessary for successful treatment. Nature Publishing Group US 2023-04-10 /pmc/articles/PMC10088695/ /pubmed/37037906 http://dx.doi.org/10.1038/s41417-023-00615-0 Text en © The Author(s), under exclusive licence to Springer Nature America, Inc. 2023, Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law. This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Review Article
Tsibulnikov, Sergey
Fayzullina, Daria
Karlina, Irina
Schroeder, Brett A.
Karpova, Olga
Timashev, Peter
Ulasov, Ilya
Ewing sarcoma treatment: a gene therapy approach
title Ewing sarcoma treatment: a gene therapy approach
title_full Ewing sarcoma treatment: a gene therapy approach
title_fullStr Ewing sarcoma treatment: a gene therapy approach
title_full_unstemmed Ewing sarcoma treatment: a gene therapy approach
title_short Ewing sarcoma treatment: a gene therapy approach
title_sort ewing sarcoma treatment: a gene therapy approach
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088695/
https://www.ncbi.nlm.nih.gov/pubmed/37037906
http://dx.doi.org/10.1038/s41417-023-00615-0
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