Raman spectroscopy for viral diagnostics

Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including c...

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Detalles Bibliográficos
Autores principales: Lukose, Jijo, Barik, Ajaya Kumar, Mithun N, Sanoop Pavithran M, George, Sajan D., Murukeshan, V. M., Chidangil, Santhosh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088700/
https://www.ncbi.nlm.nih.gov/pubmed/37113565
http://dx.doi.org/10.1007/s12551-023-01059-4
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author Lukose, Jijo
Barik, Ajaya Kumar
Mithun N
Sanoop Pavithran M
George, Sajan D.
Murukeshan, V. M.
Chidangil, Santhosh
author_facet Lukose, Jijo
Barik, Ajaya Kumar
Mithun N
Sanoop Pavithran M
George, Sajan D.
Murukeshan, V. M.
Chidangil, Santhosh
author_sort Lukose, Jijo
collection PubMed
description Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including conventional Raman spectroscopy, surface-enhanced Raman spectroscopy, Raman tweezer, tip-enhanced Raman Spectroscopy, and coherent anti-Stokes Raman scattering. Surface-enhanced Raman scattering can play an essential role in viral detection by multiplexing nanotechnology, microfluidics, and machine learning for ensuring spectral reproducibility and efficient workflow in sample processing and detection. The application of these techniques to diagnose the SARS-CoV-2 virus is also reviewed. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12551-023-01059-4.
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spelling pubmed-100887002023-04-12 Raman spectroscopy for viral diagnostics Lukose, Jijo Barik, Ajaya Kumar Mithun N Sanoop Pavithran M George, Sajan D. Murukeshan, V. M. Chidangil, Santhosh Biophys Rev Review Raman spectroscopy offers the potential for fingerprinting biological molecules at ultra-low concentration and therefore has potential for the detection of viruses. Here we review various Raman techniques employed for the investigation of viruses. Different Raman techniques are discussed including conventional Raman spectroscopy, surface-enhanced Raman spectroscopy, Raman tweezer, tip-enhanced Raman Spectroscopy, and coherent anti-Stokes Raman scattering. Surface-enhanced Raman scattering can play an essential role in viral detection by multiplexing nanotechnology, microfluidics, and machine learning for ensuring spectral reproducibility and efficient workflow in sample processing and detection. The application of these techniques to diagnose the SARS-CoV-2 virus is also reviewed. GRAPHICAL ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12551-023-01059-4. Springer Berlin Heidelberg 2023-04-10 /pmc/articles/PMC10088700/ /pubmed/37113565 http://dx.doi.org/10.1007/s12551-023-01059-4 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Lukose, Jijo
Barik, Ajaya Kumar
Mithun N
Sanoop Pavithran M
George, Sajan D.
Murukeshan, V. M.
Chidangil, Santhosh
Raman spectroscopy for viral diagnostics
title Raman spectroscopy for viral diagnostics
title_full Raman spectroscopy for viral diagnostics
title_fullStr Raman spectroscopy for viral diagnostics
title_full_unstemmed Raman spectroscopy for viral diagnostics
title_short Raman spectroscopy for viral diagnostics
title_sort raman spectroscopy for viral diagnostics
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088700/
https://www.ncbi.nlm.nih.gov/pubmed/37113565
http://dx.doi.org/10.1007/s12551-023-01059-4
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