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Dental caries and their microbiomes in children: what do we do now?

The oral cavity is an unique ecosystem formed by different structures, tissues, and a complex microbial community formed by hundreds of different species of bacteria, fungi, viruses, phages, and the candidate phyla radiation (CPR) group, all living in symbiosis with healthy individuals. In an opposi...

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Detalles Bibliográficos
Autores principales: Ribeiro, Apoena Aguiar, Paster, Bruce J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088930/
https://www.ncbi.nlm.nih.gov/pubmed/37056224
http://dx.doi.org/10.1080/20002297.2023.2198433
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author Ribeiro, Apoena Aguiar
Paster, Bruce J.
author_facet Ribeiro, Apoena Aguiar
Paster, Bruce J.
author_sort Ribeiro, Apoena Aguiar
collection PubMed
description The oral cavity is an unique ecosystem formed by different structures, tissues, and a complex microbial community formed by hundreds of different species of bacteria, fungi, viruses, phages, and the candidate phyla radiation (CPR) group, all living in symbiosis with healthy individuals. In an opposite state, dental caries is a biofilm-mediated dysbiosis that involves changes in the core microbiome composition and function, which leads to the demineralization of tooth tissues due to the fermentation of dietary carbohydrates, producing acid by select oral bacteria. The cariogenic biofilm is typically characterized by bacterial species with the ability of adhering to the saliva-coated tooth surface, production of exopolysaccharides-rich matrix (which will limit the diffusion of acidic products of carbohydrate fermentation), and the ability of surviving in this acidic environment. Besides years of research and dental treatment, dental caries remains the most common chronic disease in children worldwide. This article aims to bring an insightful discussion about important questions that remain unanswered in the Cariology and Oral Microbiology fields, to move Science forward, characterize the interrelationships of these communities, and understand mechanistic functions between microorganisms and the host, therefore leading to translatable knowledge that benefits the provision of care to our pediatric patients. [Figure: see text]
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spelling pubmed-100889302023-04-12 Dental caries and their microbiomes in children: what do we do now? Ribeiro, Apoena Aguiar Paster, Bruce J. J Oral Microbiol Review Article The oral cavity is an unique ecosystem formed by different structures, tissues, and a complex microbial community formed by hundreds of different species of bacteria, fungi, viruses, phages, and the candidate phyla radiation (CPR) group, all living in symbiosis with healthy individuals. In an opposite state, dental caries is a biofilm-mediated dysbiosis that involves changes in the core microbiome composition and function, which leads to the demineralization of tooth tissues due to the fermentation of dietary carbohydrates, producing acid by select oral bacteria. The cariogenic biofilm is typically characterized by bacterial species with the ability of adhering to the saliva-coated tooth surface, production of exopolysaccharides-rich matrix (which will limit the diffusion of acidic products of carbohydrate fermentation), and the ability of surviving in this acidic environment. Besides years of research and dental treatment, dental caries remains the most common chronic disease in children worldwide. This article aims to bring an insightful discussion about important questions that remain unanswered in the Cariology and Oral Microbiology fields, to move Science forward, characterize the interrelationships of these communities, and understand mechanistic functions between microorganisms and the host, therefore leading to translatable knowledge that benefits the provision of care to our pediatric patients. [Figure: see text] Taylor & Francis 2023-04-10 /pmc/articles/PMC10088930/ /pubmed/37056224 http://dx.doi.org/10.1080/20002297.2023.2198433 Text en © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.
spellingShingle Review Article
Ribeiro, Apoena Aguiar
Paster, Bruce J.
Dental caries and their microbiomes in children: what do we do now?
title Dental caries and their microbiomes in children: what do we do now?
title_full Dental caries and their microbiomes in children: what do we do now?
title_fullStr Dental caries and their microbiomes in children: what do we do now?
title_full_unstemmed Dental caries and their microbiomes in children: what do we do now?
title_short Dental caries and their microbiomes in children: what do we do now?
title_sort dental caries and their microbiomes in children: what do we do now?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088930/
https://www.ncbi.nlm.nih.gov/pubmed/37056224
http://dx.doi.org/10.1080/20002297.2023.2198433
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