Cargando…

Nanopore sequencing reveals methylation changes associated with obesity in circulating cell-free DNA from Göttingen Minipigs

Profiling of circulating cell-free DNA (cfDNA) by tissue-specific base modifications, such as 5-methylcytosines (5mC), may enable the monitoring of ongoing pathophysiological processes. Nanopore sequencing allows genome-wide 5mC detection in cfDNA without bisulphite conversion. The aims of this stud...

Descripción completa

Detalles Bibliográficos
Autores principales:	Drag, Markus Hodal, Debes, Karina Poulsdóttir, Franck, Clara Sandkamm, Flethøj, Mette, Lyhne, Mille Kronborg, Møller, Jacob Eifer, Ludvigsen, Trine Pagh, Jespersen, Thomas, Olsen, Lisbeth Høier, Kilpeläinen, Tuomas O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088973/ https://www.ncbi.nlm.nih.gov/pubmed/37032646 http://dx.doi.org/10.1080/15592294.2023.2199374

Ejemplares similares

Dietary normalization from a fat, fructose and cholesterol-rich diet to chow limits the amount of myocardial collagen in a Göttingen Minipig model of obesity
por: Andreasen, Laura Jul, et al.
Publicado: (2018)

Experimental non-alcoholic steatohepatitis in Göttingen Minipigs: consequences of high fat-fructose-cholesterol diet and diabetes
por: Schumacher-Petersen, Camilla, et al.
Publicado: (2019)

[(68)Ga]Ga-NODAGA-E[(cRGDyK)](2) Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction
por: Bentsen, Simon, et al.
Publicado: (2021)

The expression signatures in liver and adipose tissue from obese Göttingen Minipigs reveal a predisposition for healthy fat accumulation
por: Cirera, Susanna, et al.
Publicado: (2020)

Atorvastatin impairs liver mitochondrial function in obese Göttingen Minipigs but heart and skeletal muscle are not affected
por: Christiansen, Liselotte Bruun, et al.
Publicado: (2021)

Functional and morphological renal changes in a Göttingen Minipig model of obesity-related and diabetic nephropathy
por: Christoffersen, Berit Østergaard, et al.
Publicado: (2023)

Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals
por: Ludvigsen, Trine Pagh, et al.
Publicado: (2015)

Hyperinsulinaemic hypoglycaemia in non-anaesthetized Göttingen minipigs induces a counter-regulatory endocrine response and electrocardiographic changes
por: Lyhne, Mille K., et al.
Publicado: (2021)

Determination of Odor Detection Threshold in the Göttingen Minipig
por: Søndergaard, Lene Vammen, et al.
Publicado: (2010)

Spontaneous Object Recognition in the Göttingen Minipig
por: Moustgaard, Anette, et al.
Publicado: (2002)

Assessing breed integrity of Göttingen Minipigs
por: Reimer, Christian, et al.
Publicado: (2020)

NASH-inducing Diets in Göttingen Minipigs
por: Pedersen, Henrik D., et al.
Publicado: (2020)

Online histological atlas of the Göttingen minipig brain
por: Orlowski, Dariusz, et al.
Publicado: (2019)

Diet-Dependent Changes of the DNA Methylome Using a Göttingen Minipig Model for Obesity
por: Feng, Y., et al.
Publicado: (2021)

Functional analysis and transcriptional output of the Göttingen minipig genome
por: Heckel, Tobias, et al.
Publicado: (2015)

Characterisation of Gut Microbiota in Ossabaw and Göttingen Minipigs as Models of Obesity and Metabolic Syndrome
por: Pedersen, Rebecca, et al.
Publicado: (2013)

The Retrograde Connections and Anatomical Segregation of the Göttingen Minipig Nucleus Accumbens
por: Meidahl, Anders C., et al.
Publicado: (2016)

POLYRETINA restores light responses in vivo in blind Göttingen minipigs
por: Vagni, Paola, et al.
Publicado: (2022)

Exploring the K isotope composition of Göttingen minipig brain regions, and implications for Alzheimer's disease
por: Mahan, Brandon, et al.
Publicado: (2022)

Effects of Anesthesia and Species on the Uptake or Binding of Radioligands In Vivo in the Göttingen Minipig
por: Alstrup, Aage K. O., et al.
Publicado: (2013)

Cerebrospinal Fluid Characterization in Cynomolgus Monkeys, Beagle Dogs, and Göttingen Minipigs
por: Ballesteros, Cristina, et al.
Publicado: (2020)

Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs
por: Duvivier, Valérie, et al.
Publicado: (2022)

High Fat, Low Carbohydrate Diet Limit Fear and Aggression in Göttingen Minipigs
por: Haagensen, Annika Maria Juul, et al.
Publicado: (2014)

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs
por: Renner, Simone, et al.
Publicado: (2018)

Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs()
por: Lumley, Lucille, et al.
Publicado: (2021)

No robust reduction of infarct size and no-reflow by metoprolol pretreatment in adult Göttingen minipigs
por: Kleinbongard, Petra, et al.
Publicado: (2023)

First virological and pathological study of Göttingen Minipigs with Dippity Pig Syndrome (DPS)
por: Jhelum, Hina, et al.
Publicado: (2023)

Response to Novelty Correlates with Learning Rate in a Go/No-Go Task in Göttingen Minipigs
por: Lind, Nanna Marie, et al.
Publicado: (2005)

Application of Immunohistochemistry in Stereology for Quantitative Assessment of Neural Cell Populations Illustrated in the Göttingen Minipig
por: Hou, Jack, et al.
Publicado: (2012)

Experimental articular cartilage repair in the Göttingen minipig: the influence of multiple defects per knee
por: Christensen, Bjørn Borsøe, et al.
Publicado: (2015)

A minimally-invasive serial cerebrospinal fluid sampling model in conscious Göttingen minipigs
por: Bergadano, Alessandra, et al.
Publicado: (2019)

Long-acting CCK analogue NN9056 lowers food intake and body weight in obese Göttingen Minipigs
por: Christoffersen, Berit Ø., et al.
Publicado: (2019)

Obesity Development and Signs of Metabolic Abnormalities in Young Göttingen Minipigs Consuming Energy Dense Diets Varying in Carbohydrate Quality
por: Curtasu, Mihai Victor, et al.
Publicado: (2021)

The vaginal microbiome is stable in prepubertal and sexually mature Ellegaard Göttingen Minipigs throughout an estrous cycle
por: Lorenzen, Emma, et al.
Publicado: (2015)

Cognitive Performance of Göttingen Minipigs Is Affected by Diet in a Spatial Hole-Board Discrimination Test
por: Haagensen, Annika Maria Juul, et al.
Publicado: (2013)

BMP-7 Preserves Surface Integrity of Degradable-ceramic Cranioplasty in a Göttingen Minipig Model
por: Roldán, J. Camilo, et al.
Publicado: (2017)

Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome
por: Rittase, W. Bradley, et al.
Publicado: (2021)

Safety and efficacy of sFilm-FS, a novel biodegradable fibrin sealant, in Göttingen minipigs
por: Ramot, Yuval, et al.
Publicado: (2021)

Characterization of the immune system of Ellegaard Göttingen Minipigs - An important large animal model in experimental medicine
por: Pernold, Clara P.S., et al.
Publicado: (2022)

Obesity-Related Metabolome and Gut Microbiota Profiles of Juvenile Göttingen Minipigs—Long-Term Intake of Fructose and Resistant Starch
por: Curtasu, Mihai V., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_bbf936as5607k63j7k2vu6aj51