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A Giant Pheochromocytoma Presenting in Pheochromocytoma Crisis: A Case Report
Giant pheochromocytomas are rare tumors, with the majority being clinically silent. Clinically manifesting pheochromocytoma can present with symptoms of catecholamine excess, but nonspecific symptoms and variable clinical patterns of hypertension make it difficult to diagnose. Missing the diagnosis...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Journal of the Nepal Medical Association
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089003/ https://www.ncbi.nlm.nih.gov/pubmed/37203975 http://dx.doi.org/10.31729/jnma.8027 |
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author | Bogati, Kanchan Baniya, Sunil Thapa, Suresh Regmi, Upendra Krishna Karki, Niranjan Pokhrel, Manish |
author_facet | Bogati, Kanchan Baniya, Sunil Thapa, Suresh Regmi, Upendra Krishna Karki, Niranjan Pokhrel, Manish |
author_sort | Bogati, Kanchan |
collection | PubMed |
description | Giant pheochromocytomas are rare tumors, with the majority being clinically silent. Clinically manifesting pheochromocytoma can present with symptoms of catecholamine excess, but nonspecific symptoms and variable clinical patterns of hypertension make it difficult to diagnose. Missing the diagnosis can lead to cardiovascular catastrophes like a pheochromocytoma crisis and even death. We report a 45-year-old woman on antihypertensives, repeatedly visiting a hospital for recurrent headaches finally presented in a hypertensive crisis at an emergency department. Management was started along with an injection of labetalol, which led to an unpredicted abrupt blood pressure fall, and was successfully resuscitated. Imaging and plasma metanephrine studies revealed an underlying giant pheochromocytoma, which was cured after successful surgical resection. A high degree of clinical suspicion, elaborate and focused history-taking, and initial ultrasound imaging can guide us toward the early diagnosis of pheochromocytoma. Before the alpha blockade, beta-blockers should not be used in any cases of pheochromocytoma. |
format | Online Article Text |
id | pubmed-10089003 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Journal of the Nepal Medical Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-100890032023-04-12 A Giant Pheochromocytoma Presenting in Pheochromocytoma Crisis: A Case Report Bogati, Kanchan Baniya, Sunil Thapa, Suresh Regmi, Upendra Krishna Karki, Niranjan Pokhrel, Manish JNMA J Nepal Med Assoc Case Report Giant pheochromocytomas are rare tumors, with the majority being clinically silent. Clinically manifesting pheochromocytoma can present with symptoms of catecholamine excess, but nonspecific symptoms and variable clinical patterns of hypertension make it difficult to diagnose. Missing the diagnosis can lead to cardiovascular catastrophes like a pheochromocytoma crisis and even death. We report a 45-year-old woman on antihypertensives, repeatedly visiting a hospital for recurrent headaches finally presented in a hypertensive crisis at an emergency department. Management was started along with an injection of labetalol, which led to an unpredicted abrupt blood pressure fall, and was successfully resuscitated. Imaging and plasma metanephrine studies revealed an underlying giant pheochromocytoma, which was cured after successful surgical resection. A high degree of clinical suspicion, elaborate and focused history-taking, and initial ultrasound imaging can guide us toward the early diagnosis of pheochromocytoma. Before the alpha blockade, beta-blockers should not be used in any cases of pheochromocytoma. Journal of the Nepal Medical Association 2023-02 2023-02-28 /pmc/articles/PMC10089003/ /pubmed/37203975 http://dx.doi.org/10.31729/jnma.8027 Text en © The Author(s) 2018. https://creativecommons.org/licenses/by/4.0/This is an Open-Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Bogati, Kanchan Baniya, Sunil Thapa, Suresh Regmi, Upendra Krishna Karki, Niranjan Pokhrel, Manish A Giant Pheochromocytoma Presenting in Pheochromocytoma Crisis: A Case Report |
title | A Giant Pheochromocytoma Presenting in Pheochromocytoma Crisis: A Case Report |
title_full | A Giant Pheochromocytoma Presenting in Pheochromocytoma Crisis: A Case Report |
title_fullStr | A Giant Pheochromocytoma Presenting in Pheochromocytoma Crisis: A Case Report |
title_full_unstemmed | A Giant Pheochromocytoma Presenting in Pheochromocytoma Crisis: A Case Report |
title_short | A Giant Pheochromocytoma Presenting in Pheochromocytoma Crisis: A Case Report |
title_sort | giant pheochromocytoma presenting in pheochromocytoma crisis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089003/ https://www.ncbi.nlm.nih.gov/pubmed/37203975 http://dx.doi.org/10.31729/jnma.8027 |
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