A disease-associated XPA allele interferes with TFIIH binding and primarily affects transcription-coupled nucleotide excision repair

XPA is a central scaffold protein that coordinates the assembly of repair complexes in the global genome (GG-NER) and transcription-coupled nucleotide excision repair (TC-NER) subpathways. Inactivating mutations in XPA cause xeroderma pigmentosum (XP), which is characterized by extreme UV sensitivit...

Descripción completa

Detalles Bibliográficos
Autores principales: van den Heuvel, Diana, Kim, Mihyun, Wondergem, Annelotte P., van der Meer, Paula J., Witkamp, Myrèse, Lambregtse, Ferdy, Kim, Hyun-Suk, Kan, Folkert, Apelt, Katja, Kragten, Angela, González-Prieto, Román, Vertegaal, Alfred C. O., Yeo, Jung-Eun, Kim, Byung-Gyu, van Doorn, Remco, Schärer, Orlando D., Luijsterburg, Martijn S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089173/
https://www.ncbi.nlm.nih.gov/pubmed/36893274
http://dx.doi.org/10.1073/pnas.2208860120

Ejemplares similares

Ejemplares similares