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Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor
Lysosomes are catabolic organelles involved in macromolecular digestion, and their dysfunction is associated with pathologies ranging from lysosomal storage disorders to common neurodegenerative diseases, many of which have lipid accumulation phenotypes. The mechanism of lipid efflux from lysosomes...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
National Academy of Sciences
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089177/ https://www.ncbi.nlm.nih.gov/pubmed/36893262 http://dx.doi.org/10.1073/pnas.2213886120 |