OBSCN restoration via OBSCN-AS1 long-noncoding RNA CRISPR-targeting suppresses metastasis in triple-negative breast cancer

Mounting evidence implicates the giant, cytoskeletal protein obscurin (720 to 870 kDa), encoded by the OBSCN gene, in the predisposition and development of breast cancer. Accordingly, prior work has shown that the sole loss of OBSCN from normal breast epithelial cells increases survival and chemores...

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Detalles Bibliográficos
Autores principales: Guardia, Talia, Zhang, Yuqi, Thompson, Keyata N., Lee, Se Jong, Martin, Stuart S., Konstantopoulos, Konstantinos, Kontrogianni-Konstantopoulos, Aikaterini
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089184/
https://www.ncbi.nlm.nih.gov/pubmed/36877839
http://dx.doi.org/10.1073/pnas.2215553120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089184/
https://www.ncbi.nlm.nih.gov/pubmed/36877839
http://dx.doi.org/10.1073/pnas.2215553120

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