Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains

Computationally designed protein nanoparticles have recently emerged as a promising platform for the development of new vaccines and biologics. For many applications, secretion of designed nanoparticles from eukaryotic cells would be advantageous, but in practice, they often secrete poorly. Here we...

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Detalles Bibliográficos
Autores principales: Wang, Jing Yang (John), Khmelinskaia, Alena, Sheffler, William, Miranda, Marcos C., Antanasijevic, Aleksandar, Borst, Andrew J., Torres, Susana V., Shu, Chelsea, Hsia, Yang, Nattermann, Una, Ellis, Daniel, Walkey, Carl, Ahlrichs, Maggie, Chan, Sidney, Kang, Alex, Nguyen, Hannah, Sydeman, Claire, Sankaran, Banumathi, Wu, Mengyu, Bera, Asim K., Carter, Lauren, Fiala, Brooke, Murphy, Michael, Baker, David, Ward, Andrew B., King, Neil P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089191/
https://www.ncbi.nlm.nih.gov/pubmed/36888664
http://dx.doi.org/10.1073/pnas.2214556120

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