UV irradiation remodels the specificity landscape of transcription factors

Somatic mutations are highly enriched at transcription factor (TF) binding sites, with the strongest trend being observed for ultraviolet light (UV)-induced mutations in melanomas. One of the main mechanisms proposed for this hypermutation pattern is the inefficient repair of UV lesions within TF-bi...

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Detalles Bibliográficos
Autores principales: Mielko, Zachery, Zhang, Yuning, Sahay, Harshit, Liu, Yiling, Schaich, Matthew A., Schnable, Brittani, Morrison, Abigail M., Burdinski, Debbie, Adar, Sheera, Pufall, Miles, Van Houten, Bennett, Gordân, Raluca, Afek, Ariel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2023
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10089200/
https://www.ncbi.nlm.nih.gov/pubmed/36888663
http://dx.doi.org/10.1073/pnas.2217422120

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